核糖苷对大肠杆菌紫外线抗性的影响：脱氧核糖核酸合成在氨基酸预饥饿后增强紫外线抗性中的作用。
Influence of ribosides on ultraviolet resistance of Escherichia coli: role of deoxyribonucleic acid synthesis in the ultraviolet resistance enhancement after amino acid prestarvation.
作者信息
Sedliaková M, Stefunková E, Bernátová L
出版信息
J Bacteriol. 1971 Jul;107(1):16-20. doi: 10.1128/jb.107.1.16-20.1971.
Abstract
Changes in the resistance of cells of Escherichia coli B/r Hcr(+)thy(-)trp(-) to ultraviolet radiation were investigated after the following pretreatments: (i) amino acid starvation which, according to previous conclusions, enabled the cells to complete replication cycles of deoxyribonucleic acid (DNA); (ii) amino acid starvation during which the synthesis of DNA was arrested by the addition of 50 mug of cytidine per ml. The results showed that the enhancement of resistance observed after amino acid prestarvation was in correlation with the amount of DNA which was synthesized during the amino acidless period. The enhancement of resistance can be abolished by the addition of the riboside at any phase of the starvation period. This shows that the enhancement of resistance was not a consequence of the total inhibition of metabolism but of unbalanced growth which evoked the completion of replication cycles of DNA.
摘要
对大肠杆菌B/r Hcr(+)thy(-)trp(-)细胞进行以下预处理后，研究了其对紫外线辐射抗性的变化：(i) 氨基酸饥饿，根据先前的结论，这能使细胞完成脱氧核糖核酸（DNA）的复制周期；(ii) 氨基酸饥饿期间，通过每毫升添加50微克胞苷来阻止DNA的合成。结果表明，氨基酸预饥饿后观察到的抗性增强与在无氨基酸时期合成的DNA量相关。在饥饿期的任何阶段添加核苷都可消除抗性增强。这表明抗性增强不是代谢完全抑制的结果，而是引发DNA复制周期完成的生长不平衡的结果。
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本文引用的文献
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THE EFFECT OF AMINO ACID DEPRIVATION ON SUBSEQUENT DEOXYRIBONUCLEIC ACID REPLICATION.氨基酸剥夺对后续脱氧核糖核酸复制的影响。
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The effect of ultraviolet irradiation on 5-fluorouracil-pretreated bacteria.紫外线照射对经5-氟尿嘧啶预处理的细菌的影响。
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The U.V. sensitivity of bacteria: its relation to the DNA replication cycle.细菌的紫外线敏感性：其与DNA复制周期的关系。
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Changes in the radioresistance of bacteria after the inhibition of proteosynthesis in the preirradiation phase.在照射前阶段蛋白质合成受到抑制后细菌放射抗性的变化。
Folia Microbiol (Praha). 1966;11(3):169-72. doi: 10.1007/BF02901428.
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Technique for starvation of Escherichia coli of thymine.使大肠杆菌缺乏胸腺嘧啶的技术。
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10
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