中枢神经系统异常的婴儿缺乏体温调节能力。
Lack of temperature control in infants with abnormalities of central nervous system.
作者信息
Cross K W, Hey E N, Kennaird D L, Lewis S R, Urich H
出版信息
Arch Dis Child. 1971 Aug;46(248):437-43. doi: 10.1136/adc.46.248.437.
The temperature control of 11 infants with severe abnormalities of the central nervous system has been investigated. 4 were normothermic and 7 poikilothermic. Necropsy of the latter showed that either the hypothalamus was absent or disorganized, or the long tracts through the brainstem were unidentifiable, or in one case interrupted by a cervical myelocele. The lateral horn cells, sympathetic nervous system, and brown fat appeared normal. Where the normal reflex responses to warm and cool stimuli were absent, direct stimulation of the effector organs was attempted. Noradrenaline both stimulated heat production and constricted the peripheral skin vessels. Surprisingly, local application of pilocarpine or acetyl choline failed to stimulate the sweat glands which appeared normal at necropsy.
对11例中枢神经系统严重异常的婴儿进行了体温控制研究。4例体温正常，7例体温不稳定。对后者进行尸检发现，要么下丘脑缺失或结构紊乱，要么穿过脑干的长束无法辨认，或者在1例中被颈髓脊膜膨出中断。侧角细胞、交感神经系统和棕色脂肪看起来正常。在对温热和冷刺激缺乏正常反射反应的情况下，尝试直接刺激效应器官。去甲肾上腺素既能刺激产热，又能收缩外周皮肤血管。令人惊讶的是，局部应用毛果芸香碱或乙酰胆碱未能刺激汗腺，而汗腺在尸检时看起来正常。
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