Foster K G, Hey E N, O'Connell B
Arch Dis Child. 1971 Aug;46(248):444-51. doi: 10.1136/adc.46.248.444.
Sweat function has been studied as part of the full neurological examination of 50 full-term infants with malformation of the central nervous system. 26 of the children were less than 1 month old at the time of examination, and a further 10 were less than 3 months old. In those infants in whom the response to thermal stimulation was equivocal, the local response to 20 μg intradermal acetylcholine was also studied. Sweat function was normal above the level of the spinal lesion in all of the 24 infants with a lumbar meningomyelocele, but there was virtually no response to thermal or chemical stimulation of the thigh in the 9 infants with a flaccid paralysis of the legs. In 8 infants born with gross disorganization of the basal ganglia or brainstem (as later confirmed by necropsy) there was no sweat response anywhere to either thermal or chemical stimulation. Similar generalized anhidrosis was found in 4 other infants with severe hydrocephalus. These studies are consistent with the view that the eccrine sweat glands over most of the body only develop the ability to respond to acetylcholine if functionally innervated Sweat tests can provide information of prognostic value in full-term infants with defects of the CNS at birth.
作为对50名中枢神经系统畸形的足月儿进行全面神经系统检查的一部分，对其出汗功能进行了研究。26名儿童在检查时年龄小于1个月，另有10名儿童年龄小于3个月。对于那些对热刺激反应不明确的婴儿，还研究了对20μg皮内注射乙酰胆碱的局部反应。在所有24例患有腰骶部脊膜脊髓膨出的婴儿中，脊髓损伤水平以上的出汗功能正常，但9例腿部弛缓性麻痹的婴儿对大腿的热刺激或化学刺激几乎没有反应。在8例出生时基底神经节或脑干严重紊乱（尸检后来证实）的婴儿中，对热刺激或化学刺激在任何部位均无出汗反应。在其他4例患有严重脑积水的婴儿中也发现了类似的全身性无汗症。这些研究与以下观点一致，即身体大部分部位的外分泌汗腺只有在功能上受神经支配时才会发展出对乙酰胆碱作出反应的能力。出汗测试可为出生时患有中枢神经系统缺陷的足月儿提供具有预后价值的信息。
