Bayne E J, Williamson H E
Res Commun Chem Pathol Pharmacol. 1979 Aug;25(2):399-402.
The effect of furosemide on peripheral venous compliance in the absence of the diuretic effect of the drug was examined. Following bilateral ligation of the ureters, adult dogs were given furosemide, 2 mg/kg. A significant increase in peripheral venous compliance was observed as early as ten minutes after the drug was given (120% of control), and an additional increase was seen at 60 minutes after administration of the drug (136% of control). No change in peripheral venous compliance was observed in animals receiving only the furosemide vehicle, nor was there any change in animals in which bilateral nephrectomy had been performed prior to the administration of furosemide. These results indicate that furosemide produces a significant increase in peripheral venous compliance, which is independent of its diuretic action. However, the presence of the kidneys appears to be necessary for this effect.
在不存在速尿利尿作用的情况下，研究了速尿对周围静脉顺应性的影响。在双侧输尿管结扎后，给成年犬静脉注射速尿，剂量为2mg/kg。给药后十分钟，周围静脉顺应性即显著增加（为对照值的120%），给药60分钟后进一步增加（为对照值的136%）。仅接受速尿溶媒的动物，其周围静脉顺应性未发生变化；在给予速尿前已行双侧肾切除术的动物中，周围静脉顺应性也未发生任何变化。这些结果表明，速尿可使周围静脉顺应性显著增加，且这一作用与其利尿作用无关。然而，肾脏的存在似乎是产生这一效应所必需的。
