Varkarakis M J, Gaeta J F, Mirand E A, Murphy G P
J Med. 1975;6(1):65-71.
The in vitro maintenance of hypertrophic tissue with fluid containing cytotoxic drugs showed more degenerative changes in prostatic epithelium and stroma of the tissue compared with concurrently cultured aliquots of control tissue. It is suggested that theses morphological changes can be related with functional activity of the tissue. The mechanism of such an action is at present unsettled, but an interference on known enzymatic systems regulating prostatic growth seems likely. This system provides an added technique for the evaluation of drugs considered for possible therapeutic testing in human prostatic cancer states.
用含有细胞毒性药物的液体对肥大组织进行体外维持培养时，与同时培养的对照组织等分试样相比，该组织的前列腺上皮和基质出现了更多的退行性变化。提示这些形态学变化可能与组织的功能活性有关。目前这种作用的机制尚不清楚，但似乎可能干扰了调节前列腺生长的已知酶系统。该系统为评估考虑用于人类前列腺癌状态下可能的治疗试验的药物提供了一种额外的技术。
