淋巴细胞活化。I. T淋巴细胞和B淋巴细胞对植物有丝分裂原的反应。
Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.
作者信息
Janossy G, Greaves M F
出版信息
Clin Exp Immunol. 1971 Oct;9(4):483-98.
The selectivity of phytomitogens for T (thymus derived/dependent) and B (bursa-equivalent' dependent/derived) lymphocytes from the mouse spleen has been investigated. Responses of normal spleen cell cultures were compared with those of cultures of selected B cells. The latter were obtained from three sources (1) spleen cells of mice that had been thymectomized as adults, lethally irradiated and reconstituted with syngeneic bone marrow cells pretreated with anti-θ serum (2) spleen cells from congenitally athymic (nude') mice and (3) spleen cells from normal mice treated with anti-θ serum plus guinea-pig complement prior to culture. Using a variety of different culture conditions it was shown that B cells respond well to pokeweed mitogen, and poorly if at all to phytohaemagglutinin. Responsiveness to the latter mitogen in normal spleen cell cultures appears to be a property of T cells.
已对植物有丝分裂原对小鼠脾脏中T（胸腺衍生/依赖）淋巴细胞和B（法氏囊等效物依赖/衍生）淋巴细胞的选择性进行了研究。将正常脾细胞培养物的反应与选定B细胞培养物的反应进行了比较。后者来自三个来源：（1）成年后进行胸腺切除、接受致死剂量照射并用抗θ血清预处理的同基因骨髓细胞重建的小鼠的脾细胞；（2）先天性无胸腺（“裸”）小鼠的脾细胞；（3）培养前用抗θ血清加豚鼠补体处理的正常小鼠的脾细胞。使用各种不同的培养条件表明，B细胞对商陆有丝分裂原反应良好，而对植物血凝素反应不佳（如果有反应的话）。正常脾细胞培养物对后一种有丝分裂原的反应性似乎是T细胞的特性。
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