羊水巨噬细胞与无脑儿和脊柱裂的产前诊断
Amniotic fluid macrophages and the antenatal diagnosis of anencephaly and spina bifida.
作者信息
Sutherland G R, Brock D J, Scrimgeour J B
出版信息
J Med Genet. 1975 Jun;12(2):135-7. doi: 10.1136/jmg.12.2.135.
Abstract
The macrophage content of amniotic fluid has been measured and the upper limit of normal on an arbitrary scale is 41. Amongst 65 amniotic fluids collected for antenatal diagnostic studies before 22weeks' gestation there were eight which had macrophage counts ranging from 82 to 6226,three of these were shown to have anencephaly and two spina bifida. The reasons for three apparently false positives are as yet undetermined. Rhesus iso-immunized amniotic fluids were found to have macrophage counts of up to 276 and a possible explanation for this is considered. It is argued that an elevated aminotic fluid macrophage count may indicate a CNS defect or possibly other fetal abnormality.
摘要
已对羊水的巨噬细胞含量进行了测量，在任意尺度上正常上限为41。在妊娠22周前为产前诊断研究收集的65份羊水中，有8份巨噬细胞计数在82至6226之间，其中3份被证实有无脑儿，2份有脊柱裂。3例假阳性的原因尚未确定。发现恒河猴同种免疫的羊水巨噬细胞计数高达276，并对此给出了一种可能的解释。有人认为羊水巨噬细胞计数升高可能表明存在中枢神经系统缺陷或其他可能的胎儿异常。
相似文献
1
Amniotic fluid macrophages and the antenatal diagnosis of anencephaly and spina bifida.羊水巨噬细胞与无脑儿和脊柱裂的产前诊断
J Med Genet. 1975 Jun;12(2):135-7. doi: 10.1136/jmg.12.2.135.
2
3
4
Amniotic-fluid alpha-fetoprotein in the antenatal diagnosis of spina bifida.羊水甲胎蛋白在脊柱裂产前诊断中的应用
Lancet. 1973 Sep 8;2(7828):522-5. doi: 10.1016/s0140-6736(73)92347-7.
5
Prenatal diagnosis - chemical methods.产前诊断——化学方法。
Br Med Bull. 1976 Jan;32(1):16-20. doi: 10.1093/oxfordjournals.bmb.a071317.
6
Comparison of alphafetoprotein and beta-trace protein in the antenatal diagnosis of anencephaly and spina bifida.甲胎蛋白与β-微球蛋白在无脑儿和脊柱裂产前诊断中的比较。
Clin Genet. 1976 Apr;9(4):385-8. doi: 10.1111/j.1399-0004.1976.tb02267.x.
7
Amniotic fluid alpha-fetoprotein as a marker in prenatal diagnosis of neural tube defects.羊水甲胎蛋白作为神经管缺陷产前诊断的标志物。
Obstet Gynecol. 1976 Feb;47(2):148-51.
8
[Prenatal diagnosis of anencephalus and spina bifida by determination of alphafetoprotein].[通过测定甲胎蛋白对无脑儿和脊柱裂进行产前诊断]
Lakartidningen. 1975 Jan 22;72(4):236-8.
9
[Alpha 1 fetoproteins determination in the amniotic fluid -- a method for prenatal diagnosis].[羊水甲胎蛋白测定——一种产前诊断方法]
Zentralbl Gynakol. 1976;98(25):1573-8.
10
Alphafetoprotein and neural tube defects.甲胎蛋白与神经管缺陷
J Clin Pathol Suppl (R Coll Pathol). 1976;10:157-64.
引用本文的文献
1
Characterizing neuroinflammation and identifying prenatal diagnostic markers for neural tube defects through integrated multi-omics analysis.通过整合多组学分析，对神经炎症进行特征分析，并鉴定神经管缺陷的产前诊断标志物。
J Transl Med. 2024 Mar 9;22(1):257. doi: 10.1186/s12967-024-05051-8.
2
The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection.羊膜腔炎症或感染孕妇羊水中单核/巨噬细胞的来源。
J Perinat Med. 2019 Oct 25;47(8):822-840. doi: 10.1515/jpm-2019-0262.
3
The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies.正常及异常妊娠羊水白细胞的免疫表型。
Am J Reprod Immunol. 2018 Apr;79(4):e12827. doi: 10.1111/aji.12827. Epub 2018 Mar 3.
4
Enhancement of human amniotic cell growth by Ficoll-Paque gradient fractionation.通过Ficoll-Paque密度梯度离心法增强人羊膜细胞生长
In Vitro. 1981 Jan;17(1):81-90. doi: 10.1007/BF02618035.
5
Demonstration of astrocytes in cultured amniotic fluid cells of three cases with neural-tube defect.三例神经管缺陷患者培养羊水细胞中星形胶质细胞的显示
Hum Genet. 1981;56(3):365-70. doi: 10.1007/BF00274694.
6
Rapidly adhering cells in two cases of anencephaly.两例无脑儿中的快速黏附细胞。
Hum Genet. 1978 Nov 24;45(1):107-10. doi: 10.1007/BF00277582.
7
Cellular content of amniotic fluid as predictor of central nervous system malformations.羊水细胞成分作为中枢神经系统畸形的预测指标
J Med Genet. 1978 Apr;15(2):97-100. doi: 10.1136/jmg.15.2.97.
8
Alphafetoprotein and neural tube defects.甲胎蛋白与神经管缺陷
J Clin Pathol Suppl (R Coll Pathol). 1976;10:157-64.
9
Levels of beta-trace protein and lysozyme in human amniotic fluids.人羊水β-微球蛋白和溶菌酶水平
Experientia. 1976 Jan 15;32(1):53-5. doi: 10.1007/BF01932619.
本文引用的文献
1
Congenital toxoplasmosis simulating haemolytic disease of the newborn.先天性弓形虫病酷似新生儿溶血病。
J Obstet Gynaecol Br Emp. 1956 Dec;63(6):826-32. doi: 10.1111/j.1471-0528.1956.tb05569.x.
2
The incidence and significance of Hofbauer cells in the mature human placenta.霍夫鲍尔细胞在成熟人类胎盘中的发生率及意义。
J Pathol Bacteriol. 1967 Apr;93(2):710-7. doi: 10.1002/path.1700930239.
3
Ultrastructure of the cells of the amniotic fluid.羊水细胞的超微结构
J Obstet Gynaecol Br Commonw. 1968 Feb;75(2):164-71. doi: 10.1111/j.1471-0528.1968.tb02027.x.
4
Metaphase chromosomes from neonatal urine.新生儿尿液中的中期染色体。
Humangenetik. 1973;17(3):273-5. doi: 10.1007/BF00273641.
5
A cytologic study of amniotic fluid.羊水的细胞学研究。
Acta Cytol. 1973 Jul-Aug;17(4):289-98.
6
Letter: Predictive value of amniotic-fluid macrophages in gross C.N.S. defects.信函：羊水巨噬细胞在严重中枢神经系统缺陷中的预测价值。
Lancet. 1974 Mar 23;1(7856):504. doi: 10.1016/s0140-6736(74)92805-0.
7
Letter: Amniotic-fluid macrophages and anencephaly.信函：羊水巨噬细胞与无脑畸形。
Lancet. 1973 Nov 10;2(7837):1098-9. doi: 10.1016/s0140-6736(73)92720-7.
8
Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida.甲胎蛋白在无脑儿和脊柱裂产前诊断中的应用
Lancet. 1972 Jul 29;2(7770):197-9. doi: 10.1016/s0140-6736(72)91634-0.
Zotero 插件