Watanabe M
Tohoku J Exp Med. 1979 Jul;128(3):233-9. doi: 10.1620/tjem.128.233.
Tumor culture toxohormone (TCT) obtained from cultures of MBQA mouse tumor cells, a line derived from a methylcholanthrene-induced fibrosarcoma (CBA/J origin), suppressed the mitogenic responsiveness of mouse spleen cells (PHA, LPS) as well as the antibody formation to SRBC in vitro. The immunosuppressive activity of toxohormone was readily inactivated by heating at 100 degrees C or treatment with trypsin, but not by DNase and RNase treatment.
从MBQA小鼠肿瘤细胞培养物中获得的肿瘤培养毒素激素（TCT）可抑制小鼠脾细胞的促有丝分裂反应（PHA、LPS）以及体外对SRBC的抗体形成。该毒素激素的免疫抑制活性经100℃加热或用胰蛋白酶处理后很容易失活，但经DNA酶和RNA酶处理则不失活。MBQA小鼠肿瘤细胞系源自甲基胆蒽诱导的纤维肉瘤（CBA/J起源）。
