Kaneda H, Tashiro M, Murata T, Matsumoto J, Takeuchi M, Haruyama T
Tohoku J Exp Med. 1979 Oct;129(2):177-82. doi: 10.1620/tjem.129.177.
Plasma renin activities (resting PRA, post-dialysis delta PRA) were studied in 61 patients under chronic dialysis treatment. Removed sodium and removed water were estimated at each dialysis. Delta PRA/removed-sodium and delta PRA/removed-water were calculated as indices in response to the removal of sodium and water during the dialysis. 1)Resting PRA (pre-dialysis PRA) was positively correlated to delta PRA/removed-sodium, delta PRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure. Statistically significant factors controlling the resting PRA were delta PRA/removed-sodium, delta PRA//removed-water, and serum sodium concentration. Resting PRA was slightly correlated to diastolic blood pressure and age. 2)Post-dialysis PRA was significantly correlated to the resting PRA, delta PRA/removed-sodium, delta PRA/removed-water, serum sodium concentration, and age, but not to the blood pressure indices.
对61例接受慢性透析治疗的患者的血浆肾素活性（静息PRA、透析后PRA变化量）进行了研究。每次透析时估算钠清除量和水清除量。计算PRA变化量/钠清除量和PRA变化量/水清除量，作为透析期间对钠和水清除的反应指标。1）静息PRA（透析前PRA）与PRA变化量/钠清除量、PRA变化量/水清除量、血清渗透压和舒张压呈正相关，但与血清钠浓度、年龄以及脉压/舒张压呈负相关。控制静息PRA的具有统计学意义的因素为PRA变化量/钠清除量、PRA变化量/水清除量和血清钠浓度。静息PRA与舒张压和年龄呈轻度相关。2）透析后PRA与静息PRA、PRA变化量/钠清除量、PRA变化量/水清除量、血清钠浓度和年龄显著相关，但与血压指标无关。
