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氯法齐明治疗未经治疗的瘤型麻风的对照临床试验。

Controlled clinical trial of clofazimine in untreated lepromatous leprosy.

作者信息

Karat A B, Jeevaratnam A, Karat S, Rao P S

出版信息

Br Med J. 1971 Nov 27;4(5786):514-6. doi: 10.1136/bmj.4.5786.514.

DOI:10.1136/bmj.4.5786.514
PMID:4942741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1799776/
Abstract

A comparison of clofazimine and dapsone in the management of untreated lepromatous leprosy showed no significant differences between the two drugs in terms of morphological and bacterial indices. The incidence of erythema nodosum leprosum was similar in the two groups. Since dapsone is cheaper than clofazimine it remains the drug of choice for the routine management of untreated lepromatous leprosy.

摘要

氯法齐明与氨苯砜治疗未经治疗的瘤型麻风的比较显示，两种药物在形态学和细菌学指标方面无显著差异。两组中麻风结节性红斑的发生率相似。由于氨苯砜比氯法齐明便宜，它仍然是未经治疗的瘤型麻风常规治疗的首选药物。

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本文引用的文献

1
Public Health Weekly Reports for NOVEMBER 26, 1943.1943年11月26日公共卫生周报
Public Health Rep (1896). 1943 Nov 26;58(48):1729-1760.
2
MYCOBACTERIUM LEPRAE IN MICE: MINIMAL INFECTIOUS DOSE, RELATIONSHIP BETWEEN STAINING QUALITY AND INFECTIVITY, AND EFFECT OF CORTISONE.小鼠体内的麻风分枝杆菌：最小感染剂量、染色质量与传染性的关系以及可的松的作用
J Bacteriol. 1965 Feb;89(2):365-72. doi: 10.1128/jb.89.2.365-372.1965.
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TREATMENT OF LEPROSY WITH B 663 APPRAISAL OF THE PILOT TRIAL AFTER THREE YEARS.用B663治疗麻风病：三年试点试验评估
Lepr Rev. 1965 Jan;36:13-5. doi: 10.5935/0305-7518.19650004.
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"B 663" in the treatment of leprosy. Preliminary report of a pilot trial.“B 663”治疗麻风病。一项试点试验的初步报告。
Lepr Rev. 1962 Jan;33:6-10.
5
Chemotherapeutic trials in leprosy. 3. Pilot trial of a riminophenazine derivative. B.663, in the treatment of lepromatous leprosy.麻风病的化疗试验。3. 一种苯并吩嗪衍生物B.663治疗瘤型麻风病的初步试验。
Int J Lepr Other Mycobact Dis. 1967 Jan-Mar;35(1):25-33.
6
Leprosy research at the National Institutes of Health: experience with B.663 in the treatment of leprosy.美国国立卫生研究院的麻风病研究：B.663治疗麻风病的经验
Int J Lepr. 1965 Jul-Sep;33(3):Suppl:767-77.
7
Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy.氯法齐明治疗瘤型麻风反应期的双盲对照临床试验。
Br Med J. 1970 Jan 24;1(5690):198-200. doi: 10.1136/bmj.1.5690.198.