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氯法齐明对快速生长非产色分枝杆菌的体外活性

In vitro activity of clofazimine against rapidly growing nonchromogenic mycobacteria.

作者信息

Ausina V, Condom M J, Mirelis B, Luquin M, Coll P, Prats G

出版信息

Antimicrob Agents Chemother. 1986 May;29(5):951-2. doi: 10.1128/AAC.29.5.951.

DOI:10.1128/AAC.29.5.951
PMID:3729356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284191/
Abstract

The in vitro activity of clofazimine against 80 isolates of rapidly growing nonchromogenic mycobacteria was studied by an agar dilution method. The drug inhibited 96% of strains tested at concentrations less than or equal to 1 microgram/ml, and it appears to be an agent of potential efficacy against Mycobacterium fortuitum and M. chelonae.

摘要

采用琼脂稀释法研究了氯法齐明对80株快速生长非产色分枝杆菌的体外活性。该药物在浓度小于或等于1微克/毫升时可抑制96%的受试菌株，它似乎是一种对偶然分枝杆菌和龟分枝杆菌有潜在疗效的药物。

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本文引用的文献

1
Identification of clinically significant Mycobacterium fortuitum complex isolates.具有临床意义的偶然分枝杆菌复合群菌株的鉴定。
J Clin Microbiol. 1981 Dec;14(6):686-91. doi: 10.1128/jcm.14.6.686-691.1981.
2
Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution.快速生长分枝杆菌：采用肉汤微量稀释法检测对34种抗菌药物的敏感性
Antimicrob Agents Chemother. 1982 Aug;22(2):186-92. doi: 10.1128/AAC.22.2.186.
3
Controlled clinical trial of clofazimine in untreated lepromatous leprosy.氯法齐明治疗未经治疗的瘤型麻风的对照临床试验。
Br Med J. 1971 Nov 27;4(5786):514-6. doi: 10.1136/bmj.4.5786.514.
4
Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy.氯法齐明治疗瘤型麻风反应期的双盲对照临床试验。
Br Med J. 1970 Jan 24;1(5690):198-200. doi: 10.1136/bmj.1.5690.198.
5
Enhancement by clofazimine and inhibition by dapsone of production of prostaglandin E2 by human polymorphonuclear leukocytes in vitro.氯法齐明对人多形核白细胞体外前列腺素E2生成的增强作用及氨苯砜的抑制作用。
Antimicrob Agents Chemother. 1985 Feb;27(2):257-62. doi: 10.1128/AAC.27.2.257.
6
Antimycobacterial activity of some potential chemotherapeutic compounds.某些潜在化疗化合物的抗分枝杆菌活性。
Tubercle. 1978 Jun;59(2):135-8. doi: 10.1016/0041-3879(78)90016-8.
7
Activity of some antileprosy compounds against Mycobacterium intracellulare in vitro.某些抗麻风病化合物对细胞内分枝杆菌的体外活性。
Am Rev Respir Dis. 1977 Apr;115(4):705-8. doi: 10.1164/arrd.1977.115.4.705.