Fairshter R D, Dabir-Vaziri N, Smith W R, Glauser F L, Wilson A F
Toxicology. 1979 Mar-Apr;12(3):259-66. doi: 10.1016/0300-483x(79)90071-4.
Paraquat concentrations were measured in tissue, serum, urine and hemodialysate obtained from 3 patients who died 16.5 h, 22 days and 23 days after ingestion. In the patient who died 16.5 h post-ingestion, tissue paraquat levels were high. Kidney and liver had paraquat concentrations of 14 micrograms/g and 13.2 micrograms/g respectively, whereas lung tissue had a paraquat level of 3.8 micrograms/g. Low concentrations of paraquat were detectable in the tissues of the patients who died 22 and 23 days post-ingestion. Early in the poisoning, serum paraquat levels were high and large quantities of paraquat could be removed by both hemodialysis and forced diuresis. During an 8-h period, 713 mg of paraquat were removed by hemodialysis and 340 mg by forced diuresis. After the day of ingestion, little paraquat could be removed by hemodialysis or by forced diuresis; however, at all stages of the poisoning studied, hemodialysis was more effective than forced diuresis in removing paraquat from the blood.
对3例百草枯中毒患者在摄入百草枯16.5小时、22天和23天后死亡时所获得的组织、血清、尿液和血液透析液中的百草枯浓度进行了测定。摄入后16.5小时死亡的患者，其组织中的百草枯水平较高。肾脏和肝脏的百草枯浓度分别为14微克/克和13.2微克/克，而肺组织中的百草枯水平为3.8微克/克。在摄入后22天和23天死亡的患者组织中可检测到低浓度的百草枯。在中毒早期，血清百草枯水平较高，血液透析和强制利尿均可清除大量百草枯。在8小时内，血液透析清除了713毫克百草枯，强制利尿清除了340毫克。摄入后的当天之后，血液透析或强制利尿几乎不能清除百草枯；然而，在所研究的中毒的各个阶段，血液透析在从血液中清除百草枯方面比强制利尿更有效。
