Spector D, Whorton D, Zachary J, Slavin R
Johns Hopkins Med J. 1978 Apr;142(4):110-3.
A 27-year-old male died 30 1/2 hours following ingestion of paraquat. Hemodialysis removed 72 mg of paraquat, which represented only 2% of the calculated absorbed dose; paraquat concentrations were determined in post-mortem tissue and were high in the lungs and kidneys. Prominent histologic changes were already present in the lungs, which showed extensive evidence of alveolar injury, and in the adrenal gland, which showed massive selective necrosis of the zonae fasciculata and reticularis. These findings emphasize the inadequacy of treatment regimens that attempt only to remove paraquat from body tissues. Trials of treatments designed to prevent gastrointestinal absorption, including combinations of absorbents, cathartics and gut lavage, are warranted.
一名27岁男性在摄入百草枯30个半小时后死亡。血液透析清除了72毫克百草枯，这仅占计算出的吸收剂量的2%；在尸检组织中测定了百草枯浓度，肺部和肾脏中的浓度很高。肺部已经出现显著的组织学变化，显示出肺泡损伤的广泛证据，肾上腺也出现了显著变化，束状带和网状带出现大量选择性坏死。这些发现强调了仅试图从身体组织中清除百草枯的治疗方案的不足之处。有必要对旨在防止胃肠道吸收的治疗方法进行试验，包括使用吸附剂、泻药和肠道灌洗的联合应用。
