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辐射对哺乳动物腮腺的影响。第1部分:14C-亮氨酸给药后腮腺形态、摄取及清除的改变

Radiation effects on the parotid gland of mammals. Part 1: Modifications on the morphology and uptake and elimination after 14C-leucine administration.

作者信息

Cremonini D, Balzi M, Tomassi I, Becciolini A, Giannardi G, Pelù G

出版信息

Strahlentherapie. 1979 Jul;155(7):508-11.

PMID:494354
Abstract

U-14C-Leucine uptake and eliminaton in connection with morphological investigations after sublethal doses have been studied. The tracer uptake and elimination curves do not show significant differences between controls and irradiated animals, except for early appearance of initial peaks. An increased uptake of labeled amino acid was observed only 32 and 120 hours after irradiation, when sacrifices were done at the same hours of the day. The dose employed does not seem to affect in any significant way either the acinar and duct cells or other structures. Only a mild thickening of the connective tissue has been observed in the parotid of animals sacrificed at longer intervals.

摘要

研究了亚致死剂量照射后,U-14C-亮氨酸的摄取和消除情况,并进行了形态学观察。示踪剂摄取和消除曲线显示,除初始峰提前出现外,对照组和受照射动物之间无显著差异。仅在照射后32小时和120小时观察到标记氨基酸摄取增加,此时在同一天的相同时间进行处死。所用剂量似乎对腺泡和导管细胞或其他结构均无显著影响。仅在较长时间间隔处死的动物腮腺中观察到结缔组织轻度增厚。

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