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全身照射对不同组织的影响。用14C亮氨酸对大鼠进行的实验。

Effect of whole body irradiation on different tissues. Experiments with 14C leucine in the rat.

作者信息

Casati V, Nardino A, Tomassi I, Becciolini A, Rizzi M, Martelli T

出版信息

Acta Radiol Oncol Radiat Phys Biol. 1979;18(4):295-304. doi: 10.3109/02841867909128215.

DOI:10.3109/02841867909128215
PMID:525446
Abstract

The uptake and elimination of 14C leucine were analysed in controls and in rats irradiated 2 h before injection with 8 Gy whole-body irradiation. Plasma, small intestine, kidney and skin were assayed after homogenization for TCA soluble activity curves. In highly differentiated tissues with poor proliferative activity and low protein turnover, the uptake and elimination of the tracer did not appear to be affected by irradiation. In the small intestine differences between control and irradiated animals seemed significant.

摘要

分析了对照组以及在注射前2小时接受8 Gy全身照射的大鼠体内14C亮氨酸的摄取和消除情况。在匀浆后,对血浆、小肠、肾脏和皮肤进行检测,以获取三氯乙酸可溶性活性曲线。在增殖活性差且蛋白质周转率低的高度分化组织中,示踪剂的摄取和消除似乎不受照射影响。在小肠中,对照动物和受照射动物之间的差异似乎很显著。

相似文献

1
Effect of whole body irradiation on different tissues. Experiments with 14C leucine in the rat.全身照射对不同组织的影响。用14C亮氨酸对大鼠进行的实验。
Acta Radiol Oncol Radiat Phys Biol. 1979;18(4):295-304. doi: 10.3109/02841867909128215.
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14C leucine uptake in rat tissues at different times after irradiation.
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引用本文的文献

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A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.一项针对成年斯普拉格-道利大鼠的¹⁴C-亮氨酸吸收、分布、代谢及排泄(ADME)研究显示,β-羟基-β-甲基丁酸是一种代谢产物。
Amino Acids. 2015 May;47(5):917-24. doi: 10.1007/s00726-015-1920-6. Epub 2015 Jan 25.