某些硼烷和硼氢化物对5α-胆甾烷-3-酮和5β-胆甾烷-3-酮的还原反应
The reduction of 5 alpha-cholestan-3-one and 5 beta-cholestan-3-one by some boranes and hydroborates.
作者信息
Contreras R, Mendoza L
出版信息
Steroids. 1979 Aug;34(2):121-4. doi: 10.1016/0039-128x(79)90041-2.
PMID:494355
Abstract
This paper describes the high yield synthesis of 5 alpha-cholestan-3 alpha-ol and 5 beta-cholestan-3 beta-ol by the reduction of 5 alpha- and 5 beta-cholestan-3-one using using potassium and lithium-tri-sec-butyl-hydroborates as reducing reagents. Attempts to obtain the same alcohols using other bulky boranes resulted in the equatorial products.
摘要
本文描述了以钾和三仲丁基硼氢化锂作为还原剂，通过还原5α-胆甾烷-3-酮和5β-胆甾烷-3-酮高产率合成5α-胆甾烷-3α-醇和5β-胆甾烷-3β-醇。尝试使用其他大位阻硼烷来制备相同的醇类，得到的是平伏键产物。
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