Abul-Hajj Y J
Steroids. 1979 Aug;34(2):217-25. doi: 10.1016/0039-128x(79)90050-3.
Estrone and estradiol levels in tumor tissue cytosols were determined in 11 premenopausal and 20 postmenopausal women at the same time that 17 beta-hydroxysteroid dehydrogenase and estrogen receptors (ER) were carried out on their breast cancers. Estrogen receptor positive tumors showed significantly higher levels of estrone and estradiol. However, all ER negative tumors contained measurable amounts of both estradiol and estrone. Higher levels of estrone were observed in ER negative tumors which correlates well with high 17 beta-hydroxysteroid dehydrogenase activity. These results suggest that false negative receptor assays in the premenopausal women is not likely to be due to occupancy of receptors by endogenous estrogens. Furthermore, the higher estrone content in the ER negative group is probably due to high 17 beta-hydroxysteroid dehydrogenase activity inherent to these tumor cells.
在对11名绝经前和20名绝经后女性的乳腺癌进行17β-羟基类固醇脱氢酶和雌激素受体（ER）检测的同时，测定了她们肿瘤组织胞质溶胶中的雌酮和雌二醇水平。雌激素受体阳性肿瘤的雌酮和雌二醇水平显著更高。然而，所有ER阴性肿瘤均含有可测量的雌二醇和雌酮。在ER阴性肿瘤中观察到较高的雌酮水平，这与高17β-羟基类固醇脱氢酶活性密切相关。这些结果表明，绝经前女性受体检测假阴性不太可能是由于内源性雌激素占据受体所致。此外，ER阴性组中较高的雌酮含量可能是由于这些肿瘤细胞固有的高17β-羟基类固醇脱氢酶活性。
