Di Fronzo G, Bertuzzi A, Saccozzi R
Tumori. 1979 Apr 30;65(2):221-8. doi: 10.1177/030089167906500211.
To determine the correlation between the response to the estradiol receptor test and some fundamental properties of the tumor and the host, a study was conducted on 337 patients. Primary carcinomas, including lobular carcinomas, and recurrences or metastases are characterized by similar frequencies of response to the estradiol receptor test (68% positive, 26% negative and 6% borderline), while normal breast tissue is characterized by a higher frequency of negative results (3% positive, 71% negative and 26% borderline). Postmenopausal patients show a shift of estradiol receptor levels towards higher values with respect to premenopausal patients. Contemporaneously, an increase in estradiol receptor concentrations with patient age is observed. The clinical stage appears in influence estradiol receptor content only in postmenopausal patients, for whom an increase in the tumor size is accompanied by a decrease in the estradiol receptor levels. The apparent association constant of the receptors assumes values ranging from 1.5 to about 300 X 10(9) M-1 and does not appear to be related to either the type of tumor tissue or to the clinical stage of the tumor, age, or menopausal status of the patients.
为了确定雌二醇受体检测结果与肿瘤及宿主的一些基本特性之间的相关性，对337例患者进行了一项研究。原发性癌，包括小叶癌，以及复发或转移灶，对雌二醇受体检测的反应频率相似（68%阳性，26%阴性，6%临界），而正常乳腺组织的阴性结果频率较高（3%阳性，71%阴性，26%临界）。绝经后患者相对于绝经前患者，其雌二醇受体水平向更高值偏移。同时，观察到雌二醇受体浓度随患者年龄增加。临床分期似乎仅在绝经后患者中影响雌二醇受体含量，对于这些患者，肿瘤大小增加时，雌二醇受体水平降低。受体的表观结合常数取值范围为1.5至约300×10⁹ M⁻¹，似乎与肿瘤组织类型、肿瘤临床分期、患者年龄或绝经状态均无关。
