前列腺癌中骨髓酸性磷酸酶的预后价值。

Prognostic value of bone marrow acid phosphatase in prostatic carcinoma.

作者信息

Alsabti E A, Safo M

出版信息

Urol Int. 1979;34(5):350-5. doi: 10.1159/000280280.

Abstract

The total and l-tartrate labile acid phosphatase were studied in 25 patients with carcinoma of prostate. The results were compared with the results from a control group. Serum acid phosphatase levels both in the control groups and in patients with prostatic cancer were lower than bone marrow acid phosphatase levels. This may be due to acid phosphatase released from blood cells during hemolysis. A positive correlation between serum and bone marrow acid phosphatase levels in patients with prostatic carcinoma was found. There was a significant rise in bone marrow acid phosphatase levels (above the normal range from the control group) in patients with advanced stage III and stage IV prostatic carcinoma with significantly increased serum levels. The levels of bone marrow acid phosphatase gave a supplementary diagnostic method in the diagnosis of prostatic carcinoma. A hypothesis that raised levels of bone marrow acid phosphatase are diagnostic of early metastasis from prostatic carcinoma is given.

摘要

对25例前列腺癌患者的总酸性磷酸酶和L-酒石酸不稳定酸性磷酸酶进行了研究。将结果与对照组的结果进行了比较。对照组和前列腺癌患者的血清酸性磷酸酶水平均低于骨髓酸性磷酸酶水平。这可能是由于溶血过程中血细胞释放出酸性磷酸酶所致。在前列腺癌患者中发现血清和骨髓酸性磷酸酶水平呈正相关。在晚期III期和IV期前列腺癌患者中，骨髓酸性磷酸酶水平显著升高（高于对照组的正常范围），血清水平也显著升高。骨髓酸性磷酸酶水平为前列腺癌的诊断提供了一种辅助诊断方法。提出了一个假设，即骨髓酸性磷酸酶水平升高可诊断前列腺癌早期转移。