Keele B B, Powell H L, Navia J M, McGhee J
Appl Microbiol. 1971 Dec;22(6):957-62. doi: 10.1128/am.22.6.957-962.1971.
Actinobolin, a known inhibitor of protein synthesis, has been shown not to interfere selectively with acid production or dextransucrase activity in a cariogenic streptococcus when the antibiotic is added to a concentration of 500 mug/ml. It has also been shown that actinobolin does not alter the total in vivo flora of the oral cavity of the rat when tested in a rat caries model system. A culture of cariogenic streptococci, adapted to in vitro growth in the presence of 1 mg of actinobolin per ml, has also been isolated.
放线菌素，一种已知的蛋白质合成抑制剂，当抗生素添加到浓度为500微克/毫升时，已证明它不会选择性地干扰致龋链球菌的产酸或葡聚糖蔗糖酶活性。在大鼠龋齿模型系统中进行测试时，还表明放线菌素不会改变大鼠口腔内的体内总菌群。此外，还分离出了一种适应于在每毫升含有1毫克放线菌素的条件下进行体外生长的致龋链球菌培养物。
