Fitzgerald R J
Antimicrob Agents Chemother. 1972 Apr;1(4):296-302. doi: 10.1128/AAC.1.4.296.
A variety of antibiotic and chemotherapeutic agents were tested for their ability to inhibit the development of dental caries in Sprague-Dawley rats receiving the drugs in a coarse-particle sucrose-containing diet. Drugs which inhibit gram-positive microorganisms were effective inhibitors of caries, whereas agents which are active solely against gram-negative bacteria did not inhibit caries development. In vivo efficacy of the agents tested generally, but not invariably, paralleled in vitro inhibition of the growth of Streptococcus mutans strain FA-1, an organism which was isolated from carious Sprague-Dawley rats and which is known to induce caries in gnotobiotic Sprague-Dawley rats. Caries was significantly inhibited when 1-ephenamine penicillin (20 units/mg) was administered intermittently in the diet, 1 day per week or 1 week of every 4 weeks, but protection against caries was greatest when the same amount of the drug was fed continuously.
对多种抗生素和化疗药物进行了测试，以检验它们在含粗颗粒蔗糖饮食中给斯普拉格-道利大鼠用药时抑制龋齿发展的能力。抑制革兰氏阳性微生物的药物是有效的龋齿抑制剂，而仅对革兰氏阴性细菌有活性的药物则不能抑制龋齿发展。一般而言，但并非总是如此，所测试药物的体内疗效与体外对变形链球菌FA-1菌株生长的抑制作用平行，该菌株是从患龋的斯普拉格-道利大鼠中分离出来的，已知能在无菌斯普拉格-道利大鼠中诱发龋齿。当在饮食中间歇性给药1-表麻黄碱青霉素（20单位/毫克），每周1天或每4周1周时，龋齿得到显著抑制，但当连续投喂相同量的药物时，对龋齿的预防效果最佳。
