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[早期视觉剥夺对脑视觉分析器中谷氨酸脱羧酶活性的影响]

[Effect of early visual deprivation on glutamate decarboxylase activity in the visual analyzer of the brain].

作者信息

Agaev T M, Pigareva Z D

出版信息

Vopr Med Khim. 1979 Sep-Oct;25(5):530-3.

PMID:494536
Abstract

Early vision deprivation decreased in dogs (45-days age) the activity of glutamate decarboxylase in all the structures of brain visual analyzer studied as well as decreased the enzyme activation by exogenous pyridoxal-5-phosphate. With areing (in 90-days old dogs) the deprivation proved to be less effective in relation to decrease in the glutamate decarboxylase activity in external geniculate body but caused the same affect in the visual zone of brain cortex and in anterior mesencephalon. The deprivation exhibited similar effect on formation of asparaginic acid.

摘要

早期视觉剥夺降低了犬(45日龄)脑视觉分析器所有研究结构中谷氨酸脱羧酶的活性,同时也降低了外源性磷酸吡哆醛对该酶的激活作用。随着年龄增长(90日龄犬),视觉剥夺对外侧膝状体中谷氨酸脱羧酶活性降低的影响较小,但对大脑皮层视觉区和中脑前部产生相同影响。视觉剥夺对天冬氨酸的形成也表现出类似作用。

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