Veilleux R
Lab Invest. 1975 Jul;33(1):80-7.
Rats were maintained on a magnesium-deficient diet for 1 to 5 weeks to study the mast cell (MC) populations in their duodenum and kidney. A marked increase of intestinal subepithelial mast cells was observed in these animals as compared with normal controls. The cells in both groups showed an identical reaction for mucopolysaccharides but the 5-hydroxytryptamine content tended to be higher in the cells of magnesium-deficient animals. Proliferation of MC was also observed in the renal cortex of the magnesium-deficient rats. This finding is significant because MC are known to be virtually absent from normal kidneys. Magnesium deprivation resulted in numerous MC not only in the intertubular spaces but also within the glomeruli. Possible correlations between these and other pertinent observations are discussed with regard to certain renal diseases. The discussion is extended to the possible mechanism through which magnesium could influence secretory processes in MC.
将大鼠置于缺镁饮食环境中1至5周，以研究其十二指肠和肾脏中的肥大细胞（MC）群体。与正常对照组相比，这些动物的肠道上皮下肥大细胞显著增加。两组细胞对黏多糖的反应相同，但缺镁动物的细胞中5-羟色胺含量往往更高。在缺镁大鼠的肾皮质中也观察到肥大细胞增殖。这一发现具有重要意义，因为已知正常肾脏中几乎不存在肥大细胞。缺镁不仅导致肾小管间隙出现大量肥大细胞，肾小球内也有。针对某些肾脏疾病，讨论了这些观察结果与其他相关观察之间可能存在的关联。讨论还延伸至镁可能影响肥大细胞分泌过程的潜在机制。
