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母婴脐血三联体中的Gn同种异型。自体胎儿IgG向母亲的选择性转移。

Gn allotypes in mother-father-cord trios. A selective transfer of autologous, fetal IgG to the mother.

作者信息

Williams R C, Gershowitz H

出版信息

Vox Sang. 1979;37(2):96-102. doi: 10.1111/j.1423-0410.1979.tb02277.x.

Abstract

When tested at a standard dilution (1:30), mother-cord Gm phenotypes are identical. A more sensitive assay reveals that the fetus does possess paternal antigen, that is, does produce small amounts of autologous IgG. The paternal antigens, in both the mother and the cord plasma, appear in a mosaic, one that suggests the fetus has the ability to selectively transfer his own IgG subclasses to the mother.

摘要

在标准稀释度(1:30)下进行检测时,母婴的Gm表型是相同的。一种更灵敏的检测方法显示,胎儿确实拥有父系抗原,也就是说,确实会产生少量自身IgG。母血和脐血血浆中的父系抗原呈镶嵌式分布,这表明胎儿有能力将自身的IgG亚类选择性地转移给母亲。

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