免疫球蛋白G亚类的胎盘转运。
Placental transfer of immunoglobulin G subclasses.
作者信息
Garty B Z, Ludomirsky A, Danon Y L, Peter J B, Douglas S D
机构信息
Kipper Institute of Allergy and Immunology, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva, Israel.
出版信息
Clin Diagn Lab Immunol. 1994 Nov;1(6):667-9. doi: 10.1128/cdli.1.6.667-669.1994.
Abstract
The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B.
摘要
对34例平均胎龄25周（范围18至35周）的胎儿脐血中的总免疫球蛋白G（IgG）及其四个亚类的浓度进行了测定。通过经皮脐血采样获取血样，并将结果与母亲相应的IgG亚类浓度进行比较。确定了不同IgG亚类的胎盘转运效率。发现IgG1和IgG4的转运效率明显高于IgG3和IgG2。IgG2是从母亲向胎儿转运效率最低的亚类。这些差异可能部分解释了新生儿对各种病原体（如B族链球菌）的易感性。
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