黏膜皮肤念珠菌病、无反应性及细胞免疫的血浆抑制物：两性霉素B治疗后逆转
Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy.
作者信息
Paterson P Y, Semo R, Blumenschein G, Swelstad J
出版信息
Clin Exp Immunol. 1971 Nov;9(5):595-602.
Abstract
A patient with chronic mucocutaneous candidiasis and cutaneous anergy has been studied and found to have a circulating plasma factor capable of quenching lymphocyte responses of leucocytes of clinically well donors to monilia and other specific mitogenic stimulants. After instituting systemic amphotericin B therapy, the patient exhibited rapid clearing of cutaneous and mucosal lesions and the plasma inhibitor was no longer demonstrable. Loss of the plasma inhibitor was followed by appearance of strong cutaneous hypersensitivity and leucocyte responses to and streptococcal products. These clinical immunologic studies have pointed meaning in relationship to current views regarding immunologic reconstitution systemic antifungal therapy in treatment of chronic candidiasis.
摘要
对一名患有慢性黏膜皮肤念珠菌病和皮肤无反应性的患者进行了研究，发现其循环血浆中有一种因子，能够抑制临床上健康供体白细胞对念珠菌及其他特定促有丝分裂刺激物的淋巴细胞反应。在开始全身两性霉素B治疗后，患者的皮肤和黏膜病变迅速消退，血浆中的抑制剂也不再能检测到。血浆抑制剂消失后，患者出现了强烈的皮肤超敏反应以及白细胞对念珠菌和链球菌产物的反应。这些临床免疫学研究对于当前有关慢性念珠菌病治疗中全身抗真菌治疗免疫重建的观点具有重要意义。
相似文献
1
Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy.黏膜皮肤念珠菌病、无反应性及细胞免疫的血浆抑制物：两性霉素B治疗后逆转
Clin Exp Immunol. 1971 Nov;9(5):595-602.
2
Transfer factor as an approach to the treatment of immune deficiency disease.转移因子作为治疗免疫缺陷疾病的一种方法。
Birth Defects Orig Artic Ser. 1975;11(1):436-40.
3
Transfer of cellular hypersensitivity in chronic mucocutaneous candidiasis monitored in vivo and in vitro.慢性黏膜皮肤念珠菌病中细胞超敏反应的体内和体外监测转移
Cell Immunol. 1970 Sep;1(3):290-9. doi: 10.1016/0008-8749(70)90050-x.
4
Chronic mucocutaneous candidiasis of the adult. A report of a patient with an associated thymoma.
Arch Dermatol. 1972 Jan;105(1):96-8.
5
Effect of transfer factor on lymphocyte function in anergic patients.转移因子对无反应性患者淋巴细胞功能的影响。
J Clin Invest. 1972 Nov;51(11):2948-58. doi: 10.1172/JCI107119.
6
Lymphocyte stimulation in Candida albicans infections.白色念珠菌感染中的淋巴细胞刺激
Sabouraudia. 1974 Mar;12(1):87-94.
7
Effects of fetal thymus transplantation on defective cellular immunity.胎儿胸腺移植对缺陷性细胞免疫的影响。
Birth Defects Orig Artic Ser. 1975;11(1):367-9.
8
Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis.转移因子治疗1例慢性黏膜皮肤念珠菌病
Cell Immunol. 1972 Apr;3(4):606-15. doi: 10.1016/0008-8749(72)90122-0.
9
Use of transfer factor in patients with depressed cellular immunity and chronic infection.转移因子在细胞免疫功能低下及慢性感染患者中的应用。
Birth Defects Orig Artic Ser. 1975;11(1):431-5.
10
Treatment of mucocutaneous candidasis with transfer factor.
Pediatrics. 1974 Jan;53(1):63-70.
引用本文的文献
1
Immunohistochemical evaluation of T cells in oral lesions from human immunodeficiency virus-positive persons with oropharyngeal candidiasis.对患有口咽念珠菌病的人类免疫缺陷病毒阳性者口腔病变中T细胞的免疫组织化学评估。
Infect Immun. 2003 Feb;71(2):956-63. doi: 10.1128/IAI.71.2.956-963.2003.
2
An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single family.在一个家族中，一种导致显性慢性黏膜皮肤念珠菌病和甲状腺疾病的免疫缺陷基因定位于2号染色体短臂。
Am J Hum Genet. 2001 Oct;69(4):791-803. doi: 10.1086/323611. Epub 2001 Aug 21.
3
Characterization of the cellular immune function of patients with chronic mucocutaneous candidiasis.慢性黏膜皮肤念珠菌病患者细胞免疫功能的特征分析。
Clin Exp Immunol. 2001 Feb;123(2):247-53. doi: 10.1046/j.1365-2249.2001.01430.x.
4
Use of cellular depletion analysis to examine circulation of immune effector function between the vagina and the periphery.利用细胞耗竭分析来检测阴道与外周之间免疫效应功能的循环情况。
Infect Immun. 1997 Sep;65(9):3939-43. doi: 10.1128/iai.65.9.3939-3943.1997.
5
Immunopathogenesis of recurrent vulvovaginal candidiasis.复发性外阴阴道念珠菌病的免疫发病机制。
Clin Microbiol Rev. 1996 Jul;9(3):335-48. doi: 10.1128/CMR.9.3.335.
6
Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis.实验性阴道念珠菌病小鼠中念珠菌特异性Th1型反应性
Infect Immun. 1993 Oct;61(10):4202-7. doi: 10.1128/iai.61.10.4202-4207.1993.
7
Effects of preinduced Candida-specific systemic cell-mediated immunity on experimental vaginal candidiasis.预先诱导的念珠菌特异性全身细胞介导免疫对实验性阴道念珠菌病的影响。
Infect Immun. 1994 Mar;62(3):1032-8. doi: 10.1128/iai.62.3.1032-1038.1994.
8
Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis.在患有实验性阴道念珠菌病的小鼠中可证明存在念珠菌特异性细胞介导免疫。
Infect Immun. 1993 May;61(5):1990-5. doi: 10.1128/iai.61.5.1990-1995.1993.
9
Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity.经原发性阴道白色念珠菌感染免疫的小鼠会产生获得性阴道黏膜免疫。
Infect Immun. 1995 Feb;63(2):547-53. doi: 10.1128/iai.63.2.547-553.1995.
10
Radioimmunoassays that use 125I-labeled protein A for determination of Histoplasma capsulatum-specific immunoglobulin G, A, and M class antibodies in histoplasmosis.使用125I标记的蛋白A进行放射免疫测定，以检测组织胞浆菌病中荚膜组织胞浆菌特异性免疫球蛋白G、A和M类抗体。
J Clin Microbiol. 1981 Jan;13(1):66-72. doi: 10.1128/jcm.13.1.66-72.1981.
本文引用的文献
1
Extensive cutaneous moniliasis. Treatment with amphotericin B.
Am J Dis Child. 1961 Aug;102:168-79. doi: 10.1001/archpedi.1961.02080010170004.
2
The susceptibility to moniliasis in children with endocrine hypofunction.内分泌功能减退患儿对念珠菌病的易感性。
Trans Assoc Am Physicians. 1967;80:236-49.
3
One-way stimulation in mixed leukocyte cultures.混合白细胞培养中的单向刺激。
Science. 1966 Jul 29;153(3735):545-7. doi: 10.1126/science.153.3735.545.
4
Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infection.成年细菌感染患者中性粒细胞对硝基蓝四氮唑的自发体外还原作用。
N Engl J Med. 1971 Aug 5;285(6):311-7. doi: 10.1056/NEJM197108052850603.
5
Transfer factor.转移因子
Adv Immunol. 1969;11:195-266. doi: 10.1016/s0065-2776(08)60480-0.
6
Studies of PPLO infection. V. Inhibition of lymphocyte mitosis and antibody formation by mycoplasmal extracts.类胸膜肺炎微生物感染的研究。V. 支原体提取物对淋巴细胞有丝分裂和抗体形成的抑制作用。
J Exp Med. 1969 Jun 1;129(6):1163-81. doi: 10.1084/jem.129.6.1163.
7
Immunological observations in chronic mucocutaneous candidiasis.慢性黏膜皮肤念珠菌病的免疫学观察
Lancet. 1969 Sep 13;2(7620):567-71. doi: 10.1016/s0140-6736(69)90264-5.
8
Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid.中性粒细胞的感染与硝基蓝四氮唑还原反应。一种诊断性酸。
Lancet. 1968 Sep 7;2(7567):532-4. doi: 10.1016/s0140-6736(68)92406-9.
9
Chronic mucocutaneous candidiasis, deficiency of delayed hypersensitivity, and selective local antibody defect.慢性黏膜皮肤念珠菌病、迟发型超敏反应缺陷和选择性局部抗体缺陷。
Lancet. 1967 Sep 30;2(7518):688-93. doi: 10.1016/s0140-6736(67)90974-9.
Zotero 插件