Fidel P L, Luo W, Chabain J, Wolf N A, Van Buren E
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112, USA.
Infect Immun. 1997 Sep;65(9):3939-43. doi: 10.1128/iai.65.9.3939-3943.1997.
Results from an animal model of vaginal candidiasis suggest that Candida-specific cell-mediated immunity in the systemic circulation does not mediate protection against vaginitis. The present study used cellular depletion analysis to examine the circulation of immune effector function between the vagina and the periphery. Results showed that anti-Thy-1.2 antibodies given intravenously to mice depleted Thy-1+ T lymphocytes in the systemic compartment but not in the vaginal mucosa, while the same antibodies injected intravaginally significantly reduced Thy-1+ T cells in both the vaginal and systemic compartments. These results support a lack or low level of circulation of immune effector function from the periphery to the vaginal mucosa.
阴道念珠菌病动物模型的结果表明，全身循环中念珠菌特异性细胞介导的免疫并不介导对阴道炎的保护作用。本研究采用细胞耗竭分析来检测阴道和外周之间免疫效应功能的循环情况。结果显示，静脉注射抗Thy-1.2抗体可使小鼠全身区室中的Thy-1+ T淋巴细胞耗竭，但阴道黏膜中的Thy-1+ T淋巴细胞未被耗竭，而经阴道注射相同抗体则可显著减少阴道和全身区室中的Thy-1+ T细胞。这些结果支持从外周到阴道黏膜的免疫效应功能缺乏或循环水平较低。
