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[爱沙尼亚苏维埃社会主义共和国人群中的抗白喉和抗破伤风抗毒素免疫指数(计划免疫预防效果评估)]

[Antidiphtheria and antitetanus antitoxic immunity indices in the population of the Estonian SSR (an assessment of the effectiveness of a planned vaccine prophylaxis)].

作者信息

Maĭskaia L M, Basova N N, Bolotovskiĭ V M, Tamm O M, Miartin Ia K

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1979 Aug(8):21-6.

PMID:494896
Abstract

In 1972-1974 and 1977 in the Estonian SSR children and adults were surveyed for the presence of antibodies against tetanus and diphtheria toxins (toxoids) by means of the passive hemagglutination test. The level of protection against tetanus was revealed to correspond to the proportion of child population covered by vaccination: in 1977, with 98.8% covered by vaccination, the level of protection among children aged 7 to 14 years and adolescents of 15-19 years exceeded 98%; with the increase of age (every 10-15 years) the level of protection against tetanus regularly decreased. This dynamics correlated with the existing terms of postvaccinal immunity and the epidemiological independence of tetanus as infectiion. The level of protection in child population against diphtheria in 1972-1974 and 1977 lagged behind the level of protection against tetanus and the coverage by vaccination. The diphtheria component of adsorbed DPT vaccine seemed to be unable to ensure the sufficient level and intensity of immunity under conditions of a sharply decreased risk of encounter with the infective agent. In persons aged 40 years and over the indices of immunity against diphtheria were higher than against tetanus. These indices resulted from diphtheria infection at the prevaccination period and could serve as an objective sign in following up the decrease of the process of diphtheria epidemics.

摘要

1972年至1974年以及1977年,在爱沙尼亚苏维埃社会主义共和国,通过被动血凝试验对儿童和成人进行了破伤风和白喉毒素(类毒素)抗体检测。结果显示,破伤风的保护水平与接种疫苗的儿童人口比例相对应:1977年,接种疫苗覆盖率达98.8%,7至14岁儿童和15至19岁青少年的保护水平超过98%;随着年龄增长(每10至15岁),破伤风的保护水平有规律地下降。这种动态变化与疫苗接种后免疫的现有情况以及破伤风感染的流行病学独立性相关。1972年至1974年以及1977年儿童人群对白喉的保护水平落后于破伤风的保护水平和疫苗接种覆盖率。在接触传染源风险急剧降低的情况下,吸附百白破疫苗中的白喉成分似乎无法确保足够的免疫水平和强度。40岁及以上人群对白喉的免疫指标高于破伤风。这些指标源于接种疫苗前的白喉感染,可作为追踪白喉流行过程下降情况的客观标志。

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