[斯维尔德洛夫斯克市及斯维尔德洛夫斯克州白喉和破伤风计划疫苗预防的免疫效果评估]

[Evaluation of the immunological effectiveness of the planned vaccinal prophylaxis of diphtheria and tetanus in Sverdlovsk and Sverdlovsk Province].

作者信息

Ivchenko S I, Basova N N, Kondrashova Z N

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1986 Jun(6):15-9.

Abstract

The level and intensity of antitoxic immunity to diphtheria and tetanus in children and adolescents were determined. The presence of tetanus antitoxin in titers exceeding the protective level in 96.3-98.5% of the examined children and adolescents is indicative of a high actual coverage by immunization. Protective titers against diphtheria were lower. There was no essential difference in the levels of protection in children immunized according to the vaccination schedule and in those immunized with some deviations from this schedule. A considerable part of newborns and children aged 3 months had antibodies to diphtheria and tetanus antitoxins. After the third booster immunization changes in antidiphtheria immunity characteristics occurred only in 2.5% of the vaccines and no changes in antitetanus immunity characteristics were observed.

摘要

测定了儿童和青少年对白喉和破伤风的抗毒性免疫水平及强度。在96.3% - 98.5%的受检儿童和青少年中，破伤风抗毒素滴度超过保护水平，这表明免疫接种的实际覆盖率很高。对白喉的保护性滴度较低。按照免疫程序接种疫苗的儿童和未完全按照该程序接种疫苗的儿童在保护水平上没有本质区别。相当一部分新生儿和3个月大的儿童对白喉和破伤风抗毒素有抗体。第三次加强免疫后，仅2.5%的疫苗接种者白喉免疫特性发生变化，破伤风免疫特性未观察到变化。