Lupandin V M, Ermolina L A, Zykov M V, Korobeĭnikova I I, Dzhebrailova T D
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(10):1431-4.
The clinical efficacy of piriditol treatment in children with intellectual insufficiency was studied by means of special techniques, determining the velocity of visual information processing (VVIP) and short-time visual memory (SVM), which reflects the functional state of the brain. Piriditol was administered to 50 children aged from 7 to 12 years. The clinical state was characterized as mental retardation, due to mild organic brain lesions or oligophrenia in the form of mild debility. The use of special techniques (VVIP and SVM) for the study of intellectual activity permitted to analyze more differentially the stimulating and sedative effect of piriditol, to detect the new property of the drug, i.e. to remove the processes of fatigue in the brain tissues. A positive effect of the treatment was most marked in children with mental retardation rather than in oligophrenic patients.
通过特殊技术研究了吡硫醇治疗智力不足儿童的临床疗效，这些技术用于测定视觉信息处理速度（VVIP）和短时视觉记忆（SVM），它们反映了大脑的功能状态。对50名7至12岁的儿童施用了吡硫醇。临床状态表现为智力迟钝，原因是轻度器质性脑损伤或表现为轻度虚弱形式的智力发育不全。使用特殊技术（VVIP和SVM）研究智力活动能够更有区别地分析吡硫醇的刺激和镇静作用，检测出该药物的新特性，即消除脑组织中的疲劳过程。治疗的积极效果在智力迟钝儿童中最为明显，而非智力发育不全患者。
