Ermolina L A, Baryshnikov V A, Gorbachevskaia N L, Turova N F
Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(3):59-62.
Some biochemical and electrophysiological parameters were examined in 20 intellectually-defective children with a history of pre- and perinatal damages. Certain correlations between the character of EEG changes, the level of amino acids in the peripheral blood, and the efficacy of treatment with drugs acting upon metabolism were discovered. A marked slow-wave activity was observed on the EEG in the group of patients whose clinical course was the most unfavourable: this activity coincided with an elevated level of methionine (the source of the methyl groups in acetylcholine biosynthesis) in the peripheral blood. The therapeutic effect was the most marked in children with paroxysmal EEGs: this was accompanied in them with an increased content of functional amino acids. The data obtained are important for a more differentiated approach to the therapy of mentally retarded patients.
对20名有产前和围产期损伤史的智力缺陷儿童进行了一些生化和电生理参数检查。发现脑电图变化特征、外周血氨基酸水平与作用于代谢的药物治疗效果之间存在一定相关性。在临床病程最不利的患者组中，脑电图观察到明显的慢波活动：这种活动与外周血中蛋氨酸（乙酰胆碱生物合成中甲基的来源）水平升高相一致。脑电图阵发性的儿童治疗效果最显著：他们外周血中功能性氨基酸含量增加。所获得的数据对于更有针对性地治疗智力发育迟缓患者具有重要意义。
