Costa D L, Amdur M O
Am Ind Hyg Assoc J. 1979 Aug;40(8):680-5. doi: 10.1080/15298667991430154.
The increase in pulmonary flow resistance in unanesthetized guinea pigs was used to assess the effect of sub-micrometer oil aerosols on the response to sulfur dioxide. At a concentration of about 10 mg/m3 neither a medicinal grade mineral oil nor a light lubricating oil altered the response when given simultaneously with 1 or 10 ppm sulfur dioxide. The naphthenic medicinal oil at 100 mg/m3 failed to protect against 50 ppm sulfur dioxide when administerd simultaneously. A 30-minute pre-exposure, however, conferred complete protection. A paraffinic laboratory grade mineral oil conferred protection when given simultaneously but was less effective when the pre-exposure protocol was used.
在未麻醉的豚鼠身上，通过肺血流阻力的增加来评估亚微米油气溶胶对二氧化硫反应的影响。当药用级矿物油或轻质润滑油与1或10 ppm二氧化硫同时给予时，在约10 mg/m3的浓度下，二者均未改变反应。当环烷酸药用油以100 mg/m3的浓度与50 ppm二氧化硫同时给药时，无法起到保护作用。然而，提前30分钟暴露则可提供完全保护。当同时给予石蜡基实验室级矿物油时可起到保护作用，但采用提前暴露方案时效果较差。
