Pittillo R F, Lucas M, Blackwell R T, Woolley C
J Bacteriol. 1965 Dec;90(6):1548-51. doi: 10.1128/jb.90.6.1548-1551.1965.
Pittillo, Robert F. (Southern Research Institute, Birmingham, Ala.), Mary Lucas, Robert T. Blackwell, and Carolyn Woolley. Modification of radiation damage of bacteria by folic acid antagonists. J. Bacteriol. 90:1548-1551. 1965.-The folic acid analogues, 2,4-diamino-6-methylpteridine, amethopterin, and aminopterin, have been found to sensitize certain bacteria, especially Escherichia coli, to the lethal action of ionizing irradiation. Data are presented which indicate that (i) the compounds must be present during the irradiation period for maximal sensitization to be observed, (ii) the sensitizing effect can be nullified by cysteine or cysteamine, (iii) the sensitizing effect occurs in a number of diverse bacterial genera, and (iv) folic acid neither sensitizes bacteria to irradiation nor prevents the sensitization caused by these antifolic agents.
皮蒂洛，罗伯特·F.（阿拉巴马州伯明翰南方研究所），玛丽·卢卡斯，罗伯特·T.布莱克韦尔，以及卡罗琳·伍利。叶酸拮抗剂对细菌辐射损伤的修饰作用。《细菌学杂志》90:1548 - 1551。1965年。——已发现叶酸类似物2,4 - 二氨基 - 6 - 甲基蝶啶、氨甲蝶呤和氨基蝶呤可使某些细菌，尤其是大肠杆菌，对电离辐射的致死作用敏感。所提供的数据表明：（i）这些化合物必须在辐照期间存在才能观察到最大程度的敏化作用；（ii）半胱氨酸或半胱胺可使敏化作用失效；（iii）敏化作用在多个不同的细菌属中都会出现；（iv）叶酸既不会使细菌对辐照敏感，也不能阻止这些抗叶酸剂引起的敏化作用。
