Yusuf H K, Dickerson J W, Waterlow J C
Am J Clin Nutr. 1979 Nov;32(11):2227-32. doi: 10.1093/ajcn/32.11.2227.
The content and composition of phospholipids were studied in the brain of children who died from severe malnutrition within the first 2 years of life, and compared with those obtained from well-nourished children who died of accidents, or of illnesses not known to affect the central nervous system. Each brain was separated into the constituent major parts--the forebrain, brain stem, and the cerebellum. With the exception of a few marasmic children under 1 year of age whose forebrain and cerebellum had higher phospholipid concentration than normal, the concentration of the lipids on dry weight basis in all brain regions of the malnourished children was the same, regardless of age, as that in the children who were normal nutritionally. However, the phospholipid:DNA ratio in the forebrain and the cerebellum of most of the malnourished children under 1 year of age was higher than normal. The brain stem of only a few malnourished children aged around 1 year also had higher phospholipid:DNA ratio than normal. Among the different phospholipids, sphingomyelin was found to be selectively decreased in each brain part of the malnourished children aged 1 year or more.
对出生后两年内死于严重营养不良的儿童大脑中的磷脂含量和组成进行了研究，并与死于意外事故或已知不影响中枢神经系统疾病的营养良好儿童的大脑进行了比较。每个大脑被分离成主要组成部分——前脑、脑干和小脑。除了少数1岁以下的消瘦儿童，其前脑和小脑的磷脂浓度高于正常水平外，营养不良儿童所有脑区的脂质干重浓度与营养正常儿童相同，与年龄无关。然而，大多数1岁以下营养不良儿童前脑和小脑的磷脂:DNA比值高于正常水平。只有少数1岁左右的营养不良儿童的脑干磷脂:DNA比值也高于正常水平。在不同的磷脂中，发现1岁及以上营养不良儿童的每个脑区中鞘磷脂都有选择性降低。
