Selevich M I, Lelevich V V
Grodno State Medical Institute, Belarus.
Ukr Biokhim Zh (1978). 1998 Jan-Feb;70(1):110-2.
The effect of acute ethanol intoxication (25% solution, intragastrically, 4 g/kg, 1 h) on the concentration of phospholipid fractions in different rat brain regions was studied. It was found that acute alcohol intoxication decreased the level of phosphatidylcholine and increased the concentration of phosphatidylethanolamine in the cerebellum of experimental animals. The cortex of large hemispheres showed a decreased amount of phosphatidylcholine and increased one of sphingomyelin. Possible mechanisms of these changes are discussed.
研究了急性乙醇中毒（25%溶液，经胃内给药，4 g/kg，1小时）对不同大鼠脑区磷脂组分浓度的影响。结果发现，急性酒精中毒降低了实验动物小脑磷脂酰胆碱的水平，并增加了磷脂酰乙醇胺的浓度。大脑半球皮质显示磷脂酰胆碱含量降低，鞘磷脂含量增加。讨论了这些变化的可能机制。
