Hamrell M R, Hochstein P, Carmel R
Am J Clin Nutr. 1979 Nov;32(11):2265-8. doi: 10.1093/ajcn/32.11.2265.
Little information exists about leukocytic function in megaloblastic anemia. A report of abnormal hexose monophosphate shunt and phagocytic activity only in vitamin B12 deficiency and not in folate deficiency prompted us to examine latex-stimulated hexose monophosphate shunt activity in the two conditions. Only two of our five patients with pernicious anemia demonstrated defective activation, while one of the two folate-deficient patients also had this defect. These findings clearly indicate that hexose monophosphate shunt activity is neither consistently impaired in vitamin B12 deficiency nor consistently unaffected in folate deficiency.
关于巨幼细胞贫血中白细胞功能的信息很少。一份报告指出，仅在维生素B12缺乏而非叶酸缺乏时存在异常的磷酸己糖旁路和吞噬活性，这促使我们研究这两种情况下乳胶刺激的磷酸己糖旁路活性。我们的五名恶性贫血患者中只有两名表现出激活缺陷，而两名叶酸缺乏患者中有一名也有此缺陷。这些发现清楚地表明，磷酸己糖旁路活性在维生素B12缺乏时并非始终受损，在叶酸缺乏时也并非始终不受影响。
