Henshaw L A, Tizzard J L, Booth K, Beard M E
J Clin Pathol. 1978 Oct;31(10):960-2. doi: 10.1136/jcp.31.10.960.
Haemoglobin A2 levels were measured in 50 patients with vitamin B12 deficiency, 50 patients with folate deficiency, and six patients with combined deficiencies of these vitamins. All were normal except for three patients with vitamin B12 deficiency, who had a slightly elevated Hb A2 level; this fell to normal after vitamin B12 therapy. It is concluded that haemoglobin A2 levels are usually normal in vitamin B12 or folate deficiency. However, raised levels of haemoglobin A2 may be found, but these are not as high as is found in beta thalassaemia trait and should not cause difficutly in diagnosis.
对50例维生素B12缺乏患者、50例叶酸缺乏患者以及6例这两种维生素联合缺乏的患者进行了血红蛋白A2水平检测。除3例维生素B12缺乏患者血红蛋白A2水平略有升高外，其他患者的血红蛋白A2水平均正常；维生素B12治疗后，这3例患者的血红蛋白A2水平降至正常。研究得出结论，在维生素B12或叶酸缺乏时，血红蛋白A2水平通常正常。然而，可能会发现血红蛋白A2水平升高，但这些升高水平不如β地中海贫血特征患者那么高，且不应导致诊断困难。
