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兔体内自身抗体的产生。VII. 注射细菌后产生的针对肠道的自身抗体。

Autoantibody production in rabbits. VII. Autoantibodies to gut produced by the injection of bacteria.

作者信息

Asherson G L, Holborow E J

出版信息

Immunology. 1966 Feb;10(2):161-7.

PMID:4956607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423633/
Abstract

Rabbits received two injections of dead bacteria in Freund's complete adjuvant. One month later the sera of the rabbits were examined for autoantibodies against gut by indirect immunofluorescence using the rabbit's own stomach, ileum and colon taken at post mortem. Autoantibodies against colon were found in three out of seven rabbits injected with one particular strain of O64 and in a few animals injected with other and . The antigen, with which the autoantibodies reacted, behaved like mucus and was detected in the colon and sometimes in the ileum and the stomach. Three patterns of staining were observed: (a) staining of the superficial mucosa of the colon with sparing of the deep glands; (b) staining of scattered groups of glands in the deepest part of the colon with sparing of the superficial glands (this pattern of staining was associated with staining of the superficial mucosa of the body of the stomach); and (c) staining of both the superficial and deep glands of the colon. None of the sera tested reacted with the bronchial or salivary glands. Polysaccharide preparations of the colon, but not the stomach, inhibited the reaction of the autoantibodies with colon in the sera tested. The amount of antigen needed to inhibit the basal staining was much greater than that needed to inhibit the superficial staining. It was concluded that rabbits may produce autoantibodies to colon and in some cases to ileum and stomach following the injection of certain dead bacteria in Freund's complete adjuvant.

摘要

给兔子注射两次弗氏完全佐剂中的死细菌。一个月后，通过间接免疫荧光法，使用兔子死后取出的自身胃、回肠和结肠，检测兔子血清中针对肠道的自身抗体。在注射了一种特定O64菌株的7只兔子中，有3只以及注射了其他菌株的几只兔子体内发现了针对结肠的自身抗体。与自身抗体发生反应的抗原表现得像黏液，在结肠中被检测到，有时在回肠和胃中也能检测到。观察到三种染色模式：(a) 结肠浅表黏膜染色，深部腺体未染色；(b) 结肠最深处散在的腺体群染色，浅表腺体未染色（这种染色模式与胃体浅表黏膜染色有关）；(c) 结肠浅表和深部腺体均染色。所检测的血清均未与支气管或唾液腺发生反应。结肠的多糖制剂（而非胃的多糖制剂）可抑制所检测血清中自身抗体与结肠的反应。抑制基础染色所需的抗原量远大于抑制浅表染色所需的抗原量。得出的结论是，在弗氏完全佐剂中注射某些死细菌后，兔子可能会产生针对结肠的自身抗体，在某些情况下还会产生针对回肠和胃的自身抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/e4aa4f7b2631/immunology00421-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/e2c8b80b4947/immunology00421-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/9897fdba026f/immunology00421-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/701b0c014238/immunology00421-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/caa174ddfa87/immunology00421-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/e4aa4f7b2631/immunology00421-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/e2c8b80b4947/immunology00421-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/9897fdba026f/immunology00421-0072-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/701b0c014238/immunology00421-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/caa174ddfa87/immunology00421-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/1423633/e4aa4f7b2631/immunology00421-0075-a.jpg

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STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI.链球菌相关性肾小球肾炎。I. 12型致肾炎性链球菌及人肾小球可溶性组分的分离、免疫化学及比较化学
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