大鼠血清中的天然抗组织抗体。
Naturally occurring anti-tissue antibodies in rat sera.
作者信息
Weir D M, Pinckard R N, Elson C J, Suckling D E
出版信息
Clin Exp Immunol. 1966 Oct;1(4):433-42.
Abstract
Seventy per cent of normal rat sera have been shown to contain heat labile serum component(s) active against various rat organ homogenates as demonstrated by haemolytic complement fixation and passive haemagglutination tests. The main antigenic activity in rat liver has been found in the mitochondrial fractions. It was also demonstrated by the indirect fluorescent antibody technique that both guinea-pig complement and high molecular weight rat globulins were fixed to rat organ sections. Chemotactic activity has also been observed with rat serum and rat liver mitochondria and it is suggested that these naturally occurring antibodies may be implicated in the removal of tissue breakdown products.
摘要
已证明，70%的正常大鼠血清含有热不稳定血清成分，这些成分对各种大鼠器官匀浆具有活性，这通过溶血补体结合试验和被动血凝试验得到了证实。在大鼠肝脏中，主要的抗原活性存在于线粒体部分。间接荧光抗体技术也表明，豚鼠补体和高分子量大鼠球蛋白都能与大鼠器官切片结合。在大鼠血清和大鼠肝脏线粒体中也观察到了趋化活性，提示这些天然存在的抗体可能与组织分解产物的清除有关。
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