Brautbar N, Levine B S, Coburn J W, Kleeman C R
Am J Physiol. 1979 Nov;237(5):E428-36. doi: 10.1152/ajpendo.1979.237.5.E428.
Six conscious intact dogs were studied to evaluate the interactions of somatostatin (SRIF) with exogenous antidiuretic hormone arginine vasopressin (AVP). SRIF administration caused a significant increase in free water clearance compared to a vehicle-treated group: -0.91 (+/- 0.41 SD) ml/min to 0.21 (+/- 0.32 SD) ml/min in the experimental group (P less than 0.01) versus 0.21 (+/- 0.81 SD) ml/min to -0.21 (+/- 0.68 SD) ml/min in the control (P greater than 0.5). Six conscious, thyroparathyroidectomized dogs were studied to test the interaction of SRIF and parathyroid extract (PTE). There were no significant changes in the phosphaturic and hypocalciuric effects of PTE with SRIF administration. We conclude that acute systemic SRIF administration interferes with the antidiuretic action of AVP, probably at the renal-tubular level, but does not antagonize the renal actions of PTE.
对6只清醒且未受损的狗进行了研究，以评估生长抑素（SRIF）与外源性抗利尿激素精氨酸加压素（AVP）之间的相互作用。与接受赋形剂治疗的组相比，给予SRIF后自由水清除率显著增加：实验组从-0.91（±0.41标准差）毫升/分钟增加到0.21（±0.32标准差）毫升/分钟（P<0.01），而对照组从0.21（±0.81标准差）毫升/分钟增加到-0.21（±0.68标准差）毫升/分钟（P>0.5）。对6只清醒的甲状腺甲状旁腺切除的狗进行了研究，以测试SRIF与甲状旁腺提取物（PTE）之间的相互作用。给予SRIF后，PTE的利磷和低钙尿作用没有显著变化。我们得出结论，急性全身性给予SRIF会干扰AVP的抗利尿作用，可能是在肾小管水平，但不会拮抗PTE的肾脏作用。
