Dillmann E, Johnson D G, Martin J, Mackler B, Finch C
Am J Physiol. 1979 Nov;237(5):R297-300. doi: 10.1152/ajpregu.1979.237.5.R297.
Iron-deficient rats have increased blood and urinary catecholamines regardless of whether anemia is or is not present. The catecholamine response in both iron-deficient and control animals is largely temperature dependent, showing little difference at the isothermic temperature of 30 degrees C but a two- to threefold increase in iron-deficient animals over controls at lower temperatures. The iron-deficient rat is unable to maintain body temperature at 4 degrees C and this is independent of anemia or of food intake. When animals are run on the treadmill for 4 h, body temperatures increase but the difference observed at 4 degrees C between iron-deficient and control animals persists. The underlying abnormality in temperature regulation and in catecholamine response disappeared after 6 days of iron therapy.
缺铁大鼠无论是否存在贫血，其血液和尿液中的儿茶酚胺都会增加。缺铁动物和对照动物的儿茶酚胺反应在很大程度上取决于温度，在30摄氏度的等温温度下差异不大，但在较低温度下，缺铁动物的儿茶酚胺反应比对照动物增加两到三倍。缺铁大鼠在4摄氏度时无法维持体温，这与贫血或食物摄入量无关。当动物在跑步机上跑4小时时，体温会升高，但在4摄氏度时观察到的缺铁动物和对照动物之间的差异仍然存在。铁治疗6天后，温度调节和儿茶酚胺反应的潜在异常消失。
