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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Biochem J. 1966 May;99(2):341-6. doi: 10.1042/bj0990341.

After intravenous injections of radioactive thyroxine into cats, about half the radioactivity excreted in the bile was in a glucuronide fraction, which, after hydrolysis with beta-glucuronidase, gave rise to radioactive thyroxine and a radioactive substance that ran with 3,3',5'-tri-iodothyronine on paper chromatography in two dimensions. 2. The proportion of the total radioactivity in the bile in the glucuronide fraction was unaffected by an intravenous injection of 750mug. of non-radioactive thyroxine. 3. It is concluded that the capacity of the liver for forming the glucuronides of thyroxine and its metabolites is at least as great in cats as in monkeys. 4. These findings are discussed in relation to the question whether the liver contains one or more than one UDP-glucuronic acid glucuronyltransferase.

给猫静脉注射放射性甲状腺素后，经胆汁排泄的放射性物质中约有一半存在于葡糖醛酸苷部分，该部分经β-葡糖醛酸酶水解后，产生放射性甲状腺素和一种放射性物质，在双向纸层析中其移动情况与3,3',5'-三碘甲腺原氨酸相同。2. 静脉注射750微克非放射性甲状腺素不会影响胆汁中葡糖醛酸苷部分的放射性占总放射性的比例。3. 得出的结论是，猫肝脏形成甲状腺素及其代谢产物葡糖醛酸苷的能力至少与猴子的一样强。4. 结合肝脏中是否含有一种或多种尿苷二磷酸葡糖醛酸葡糖醛酸基转移酶这一问题对这些发现进行了讨论。

Biochem J. 1966 May;99(2):341-6. doi: 10.1042/bj0990341.

After intravenous injections of radioactive thyroxine into cats, about half the radioactivity excreted in the bile was in a glucuronide fraction, which, after hydrolysis with beta-glucuronidase, gave rise to radioactive thyroxine and a radioactive substance that ran with 3,3',5'-tri-iodothyronine on paper chromatography in two dimensions. 2. The proportion of the total radioactivity in the bile in the glucuronide fraction was unaffected by an intravenous injection of 750mug. of non-radioactive thyroxine. 3. It is concluded that the capacity of the liver for forming the glucuronides of thyroxine and its metabolites is at least as great in cats as in monkeys. 4. These findings are discussed in relation to the question whether the liver contains one or more than one UDP-glucuronic acid glucuronyltransferase.

给猫静脉注射放射性甲状腺素后，经胆汁排泄的放射性物质中约有一半存在于葡糖醛酸苷部分，该部分经β-葡糖醛酸酶水解后，产生放射性甲状腺素和一种放射性物质，在双向纸层析中其移动情况与3,3',5'-三碘甲腺原氨酸相同。2. 静脉注射750微克非放射性甲状腺素不会影响胆汁中葡糖醛酸苷部分的放射性占总放射性的比例。3. 得出的结论是，猫肝脏形成甲状腺素及其代谢产物葡糖醛酸苷的能力至少与猴子的一样强。4. 结合肝脏中是否含有一种或多种尿苷二磷酸葡糖醛酸葡糖醛酸基转移酶这一问题对这些发现进行了讨论。