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甲状腺素葡萄糖醛酸苷向胆汁中的转运。

Transport of thyroxine glucuronide into bile.

作者信息

Hillier A P

出版信息

J Physiol. 1972 Dec;227(1):195-200. doi: 10.1113/jphysiol.1972.sp010026.

Abstract
  1. The secretion of thyroxine glucuronide into bile has been investigated in the isolated perfused rat liver and also in the intact animal. Radioactive material for the study was prepared from the bile of rats treated with [(125)I]thyroxine.2. The isolated liver actively transports thyroxine glucuronide from the perfusion fluid (Tyrode solution) into the bile. At equilibrium, its concentration in the bile is about 1800 x its concentration in the perfusion fluid.3. Experiments with pulse infusions of glucuronide indicate that the substance enters the bile almost as soon as it is captured by the tissue.4. Secretion of thyroxine glucuronide is strongly inhibited by bromosulphophthalein, indicating a common carrier mechanism. It is suggested that secretion probably involves two stages - transfer from the perfusion fluid into the cell and then from the cell into the bile. The second stage is certainly active.5. When thyroxine glucuronide is injected intravenously into anaesthetized rats, some 77% is recovered from the bile, half of this being excreted within the first 14 min.
摘要
  1. 已在离体灌注大鼠肝脏以及完整动物体内研究了甲状腺素葡萄糖醛酸苷向胆汁中的分泌情况。用于该研究的放射性物质是由用[(125)I]甲状腺素处理过的大鼠胆汁制备而成。

  2. 离体肝脏能将甲状腺素葡萄糖醛酸苷从灌注液(台氏液)中主动转运至胆汁中。平衡时,其在胆汁中的浓度约为灌注液中浓度的1800倍。

  3. 对葡萄糖醛酸苷进行脉冲输注的实验表明,该物质一旦被组织摄取,几乎立即进入胆汁。

  4. 甲状腺素葡萄糖醛酸苷的分泌受到溴磺酞的强烈抑制,这表明存在一种共同的载体机制。有人提出,分泌可能涉及两个阶段——从灌注液转运至细胞,然后从细胞转运至胆汁。第二阶段肯定是主动的。

  5. 当将甲状腺素葡萄糖醛酸苷静脉注射到麻醉的大鼠体内时,约77%可从胆汁中回收,其中一半在最初的14分钟内排出。

相似文献

1
Transport of thyroxine glucuronide into bile.甲状腺素葡萄糖醛酸苷向胆汁中的转运。
J Physiol. 1972 Dec;227(1):195-200. doi: 10.1113/jphysiol.1972.sp010026.
5
Autoregulation of thyroxine secretion into bile.甲状腺素分泌入胆汁的自身调节。
J Physiol. 1972 Mar;221(2):471-6. doi: 10.1113/jphysiol.1972.sp009762.
9
Effect of salicylate on the metabolism of L-thyroxine.
Endocrinology. 1965 Sep;77(3):475-84. doi: 10.1210/endo-77-3-475.

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