Nurnberger J, Roose S P, Dunner D L, Fieve R R
Am J Psychiatry. 1979 Nov;136(11):1420-3. doi: 10.1176/ajp.136.11.1420.
Of the 241 lithium clinic patients at the New York State Psychiatric Institute with bipolar I affective disorder, 38 (15.7%) had never been hospitalized or somatically treated for depression. These "unipolar manic" patients had a significantly lower incidence of rapid cycling and suicide attempts than other bipolar I patients. No differences were found, however, in risk of illness in first-degree relatives. Lithium was an effective prophylactic agent in these patients. Some patients originally classified as "unipolar manic" were found to have depressive episodes with additional information and clinical observation. "Unipolar mania" appears to be a subgroup of bipolar I illness, but there are no data to support the hypothesis that it is a separate entity.
在纽约州精神病研究所的241名患有双相I型情感障碍的锂盐门诊患者中，38名（15.7%）从未因抑郁症住院或接受过躯体治疗。这些“单相躁狂”患者的快速循环和自杀未遂发生率明显低于其他双相I型患者。然而，在一级亲属的患病风险方面未发现差异。锂盐对这些患者是一种有效的预防药物。随着更多信息和临床观察，一些最初被归类为“单相躁狂”的患者被发现有抑郁发作。“单相躁狂”似乎是双相I型疾病的一个亚组，但没有数据支持它是一个独立实体的假设。
