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儿童弥漫性膜性肾小球肾炎

Diffuse membranous glomerulonephritis in children.

作者信息

Chan W C, Tsao Y C

出版信息

J Clin Pathol. 1966 Sep;19(5):464-9. doi: 10.1136/jcp.19.5.464.

DOI:10.1136/jcp.19.5.464
PMID:4958475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473351/
Abstract

Nine cases of diffuse membranous glomerulonephritis detected among 90 renal biopsies from children with persistent proteinuria and one necropsy case of a young child who died of chronic membranous glomerulonephritis with uraemia were studied by a variety of techniques. Clinical presentation varies within this single morphological entity and the response to steroid therapy is not yet predictable on either clinical or morphological criteria. Correlation is demonstrated between therapeutic responses and the degree of selectivity of the proteinuria which was determined by studying the relative protein clearances with an immunochemical technique.

摘要

对90例持续性蛋白尿患儿肾活检中检测出的9例弥漫性膜性肾小球肾炎病例以及1例死于慢性膜性肾小球肾炎伴尿毒症的幼儿尸检病例，采用了多种技术进行研究。在这单一的形态学类型中，临床表现存在差异，而且无论是根据临床标准还是形态学标准，对类固醇疗法的反应目前都无法预测。通过免疫化学技术研究相对蛋白清除率来确定蛋白尿的选择性程度，结果显示治疗反应与蛋白尿选择性程度之间存在相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/560d78cfa28e/jclinpath00364-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/0a637a38bb7f/jclinpath00364-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/416d4c670e38/jclinpath00364-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/6b31a7f8262f/jclinpath00364-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/8cc611aa7293/jclinpath00364-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/d7689f9fd7ce/jclinpath00364-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/884d2e5de924/jclinpath00364-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/560d78cfa28e/jclinpath00364-0056-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/0a637a38bb7f/jclinpath00364-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/416d4c670e38/jclinpath00364-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/6b31a7f8262f/jclinpath00364-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/8cc611aa7293/jclinpath00364-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/d7689f9fd7ce/jclinpath00364-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/884d2e5de924/jclinpath00364-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9d/473351/560d78cfa28e/jclinpath00364-0056-b.jpg

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1
Diffuse membranous glomerulonephritis in children.儿童弥漫性膜性肾小球肾炎
J Clin Pathol. 1966 Sep;19(5):464-9. doi: 10.1136/jcp.19.5.464.
2
The clinical course of idiopathic membranous nephropathy.特发性膜性肾病的临床病程。
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[Clinical and morphological studies in nephrotic syndrome. Report on 83 children].[肾病综合征的临床与形态学研究。83例儿童报告]
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[Primary nephrotic syndrome. Follow-up of 202 pediatric patients].[原发性肾病综合征。202例儿科患者的随访]
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引用本文的文献

1
Membranous Nephropathy and Anti-Podocytes Antibodies: Implications for the Diagnostic Workup and Disease Management.膜性肾病与抗足细胞抗体：对诊断和疾病管理的影响。
Biomed Res Int. 2018 Jan 8;2018:6281054. doi: 10.1155/2018/6281054. eCollection 2018.
2
Chapter 7: Idiopathic membranous nephropathy.第7章：特发性膜性肾病。
Kidney Int Suppl (2011). 2012 Jun;2(2):186-197. doi: 10.1038/kisup.2012.20.
3
Membranous nephropathy in children: clinical presentation and therapeutic approach.儿童膜性肾病：临床表现与治疗方法。

本文引用的文献

1
Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.组织细胞中抗原的定位；通过荧光抗体检测抗原的方法的改进。
J Exp Med. 1950 Jan 1;91(1):1-13. doi: 10.1084/jem.91.1.1.
2
Renal biopsy, with particular reference to the study of diabetes mellitus, systemic lupus erythematosus and subacute glomerulonephritis.
Australas Ann Med. 1961 Aug;10:178-91. doi: 10.1111/imj.1961.10.3.178.
3
SIGNIFICANCE OF QUANTITATIVE AND QUALITATIVE ANALYSIS OF THE PROTEINURIA IN THE NEPHROTIC SYNDROME.
J Clin Pathol. 1965 Jul;18:559-63.
4
Pediatr Nephrol. 2010 Aug;25(8):1419-28. doi: 10.1007/s00467-009-1324-5. Epub 2009 Nov 12.
4
Paired trial of cyclophosphamide and prednisone in children with nephrosis.环磷酰胺与泼尼松治疗儿童肾病的配对试验。
Arch Dis Child. 1971 Jun;46(247):327-31. doi: 10.1136/adc.46.247.327.
5
Persistent proteinuria in children.儿童持续性蛋白尿
Arch Dis Child. 1969 Aug;44(236):443-53. doi: 10.1136/adc.44.236.443.
6
Membranous glomerulonephritis.膜性肾小球肾炎
J Clin Pathol. 1986 Feb;39(2):167-71. doi: 10.1136/jcp.39.2.167.
7
The morphological and clinical course of the different forms of glomerulonephritis.不同类型肾小球肾炎的形态学及临床病程。
Klin Wochenschr. 1976 Feb 1;54(3):105-16. doi: 10.1007/BF01468787.
PERSISTENT NEPHROTIC SYNDROME: A RENAL BIOPSY STUDY.持续性肾病综合征：一项肾活检研究。
Australas Ann Med. 1964 Nov;13:306-12. doi: 10.1111/imj.1964.13.4.306.
5
SELECTIVITY OF PROTEIN EXCRETION IN PATIENTS WITH THE NEPHROTIC SYNDROME.肾病综合征患者蛋白质排泄的选择性
J Clin Invest. 1964 Dec;43(12):2332-46. doi: 10.1172/JCI105107.
6
A modified Silverman biopsy needle for use in children.一种用于儿童的改良型西尔弗曼活检针。
Lancet. 1962 Mar 31;1(7231):673. doi: 10.1016/s0140-6736(62)92886-6.
7
The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy.肾病综合征。通过肾活检以及与类固醇治疗反应相关的生化和免疫学分析进行诊断。
Q J Med. 1960 Apr;29:235-56.
8
Role of gamma globulins in pathogenesis of renal lesions in systemic lupus erythematosus and chronic membranous glomerulonephritis, with an observation on the lupus erythematosus cell reaction.γ球蛋白在系统性红斑狼疮和慢性膜性肾小球肾炎肾损害发病机制中的作用，并对红斑狼疮细胞反应的观察
J Exp Med. 1957 Aug 1;106(2):191-202. doi: 10.1084/jem.106.2.191.
9
The estimation of the individual human serum proteins by an immunological method.采用免疫学方法对个体人血清蛋白进行测定。
J Clin Pathol. 1957 Feb;10(1):67-71. doi: 10.1136/jcp.10.1.67.