Barber C, Vlădoianu I R, Dimache G
Immunology. 1967 Apr;12(4):411-6.
The antigenic relationship between and , that at present are known to share only the polysaccharide factors 9 and 12, has been investigated with a view to confirming the existence of common protein O specificity. A serum to absorbed with the polysaccharide of O-901 and a serum to in which the polysaccharide antibodies were present in extremely small amounts (undetectable in agar diffusion tests) precipitated with extracts containing proteins of . Additional evidence of the existence of common protein O factors was obtained by precipitin tests in agar in which sera to proteins from reacted with proteins of and (whose H determinants differ from one another); the precipitations of heterologous proteins in agar-gel varied in intensity according to the antibody content of the antiprotein sera tested and to the proportion of O determinants of the respective protein. Heterologous precipitin reactions of the sera to with antigens from were stronger than those with the homologous antigen, whereas the antigens from were but weakly precipitated by the sera to . This appears to indicate an intrinsically higher antigenic potency of , compared with .
目前已知仅共享多糖因子9和12的[具体物质1]与[具体物质2]之间的抗原关系已被研究，目的是确认共同蛋白O特异性的存在。用O-901的多糖吸收的针对[具体物质1]的血清以及其中多糖抗体含量极少（在琼脂扩散试验中检测不到）的针对[具体物质2]的血清，与含有[具体物质1]蛋白质的提取物发生沉淀反应。通过琼脂中的沉淀素试验获得了共同蛋白O因子存在的额外证据，在该试验中，针对[具体物质1]蛋白质的血清与[具体物质2]和[具体物质3]（其H决定簇彼此不同）的蛋白质发生反应；琼脂凝胶中异源蛋白质的沉淀强度根据所测试的抗蛋白质血清的抗体含量以及各自蛋白质的O决定簇比例而有所不同。针对[具体物质1]的血清与来自[具体物质2]的抗原的异源沉淀反应比与同源抗原的反应更强，而来自[具体物质2]的抗原仅被针对[具体物质1]的血清微弱沉淀。这似乎表明，与[具体物质2]相比，[具体物质1]具有本质上更高的抗原效力。
