胚胎胸腺中的抑制细胞介导同种异体移植耐受。
Suppressor cells in the embryonic thymus mediate allograft tolerance.
作者信息
Droege W, Tuneskog M
出版信息
Adv Exp Med Biol. 1976;66:571-6. doi: 10.1007/978-1-4613-4355-4_89.
PMID:4964
Abstract
Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompatibility difference. Suppressive activity of this kind is already found in the embryonic thymus and is therefore believed to mediate also self tolerance and neonatal allograft tolerance.
摘要
来自未免疫幼鸡的胸腺细胞可抑制轻度照射的同基因或异基因受体中的同种异体移植排斥反应，并在很大比例的受体中介导跨越强烈组织相容性差异的长期皮肤移植存活。这种抑制活性已在胚胎胸腺中发现，因此被认为也介导自身耐受性和新生儿同种异体移植耐受性。
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