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同基因胸腺细胞对同种异体移植排斥反应的免疫抑制作用。

Immunosuppressive effect of syngeneic thymus cells on allograft rejection.

作者信息

Droege W

出版信息

Proc Natl Acad Sci U S A. 1975 Jun;72(6):2371. doi: 10.1073/pnas.72.6.2371.

DOI:10.1073/pnas.72.6.2371
PMID:1094465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432760/
Abstract

Transfer of thymus cells from young chickens to syngeneic recipients suppresses the allograft rejection between strains differing at the major histocompatibility (B) locus. Thymus cell transfer in combination with a light whole body irradiation (360 R) prolongs significantly the mean rejection time of skin allografts and leads in a proportion of recipients to long-lasting graft survival (greater than 200 days). Three weeks after the cell transfer, the suppression appears to be antigen specific, as judged by the normal reactivity against third-party skin grafts. From the types of thymus cells preparations that are effective in these experiments, it is inferred that the suppressor cell is a bursa-dependent lymphocyte, which is predominantly found in the young chicken thymus and which is different from B-lymphocytes, B-precursor cells, or graft-versus-host-reactive T-cells.

摘要

将幼鸡的胸腺细胞转移至同基因受体，可抑制主要组织相容性（B）位点不同的品系之间的同种异体移植排斥反应。胸腺细胞转移联合轻度全身照射（360拉德）可显著延长皮肤同种异体移植的平均排斥时间，并使一部分受体的移植物长期存活（超过200天）。细胞转移三周后，根据对第三方皮肤移植的正常反应性判断，这种抑制似乎具有抗原特异性。从这些实验中有效的胸腺细胞制剂类型可以推断，抑制细胞是一种依赖法氏囊的淋巴细胞，主要存在于幼鸡胸腺中，与B淋巴细胞、B前体细胞或移植物抗宿主反应性T细胞不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/f356bce72fa8/pnas00049-0399-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/98dc41cee695/pnas00049-0399-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/fe2afb2b450f/pnas00049-0399-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/c246b139f1c9/pnas00049-0399-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/f356bce72fa8/pnas00049-0399-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/98dc41cee695/pnas00049-0399-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/fe2afb2b450f/pnas00049-0399-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/c246b139f1c9/pnas00049-0399-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da14/432760/f356bce72fa8/pnas00049-0399-d.jpg

相似文献

1
Immunosuppressive effect of syngeneic thymus cells on allograft rejection.同基因胸腺细胞对同种异体移植排斥反应的免疫抑制作用。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2371. doi: 10.1073/pnas.72.6.2371.
2
The antigen-inexperienced thymic suppressor cells: a class of lymphocytes in the young chicken thymus that inhibits antibody production and cell-mediated immune responses.抗原未致敏的胸腺抑制细胞：幼鸡胸腺中的一类淋巴细胞，可抑制抗体产生和细胞介导的免疫反应。
Eur J Immunol. 1976 Apr;6(4):279-87. doi: 10.1002/eji.1830060409.
3
Intrathymic injection of donor-specific X-irradiation-sensitive spleen cells abrogates accelerated rejection of cardiac allografts in sensitized rats.向胸腺内注射供体特异性X射线敏感脾细胞可消除致敏大鼠心脏同种异体移植的加速排斥反应。
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4
Abnormal response to minor histocompatibility antigens in Obese strain chickens.肥胖品系鸡对次要组织相容性抗原的异常反应。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2877-80. doi: 10.1073/pnas.73.8.2877.
5
Suppressor cells in the embryonic thymus mediate allograft tolerance.胚胎胸腺中的抑制细胞介导同种异体移植耐受。
Adv Exp Med Biol. 1976;66:571-6. doi: 10.1007/978-1-4613-4355-4_89.
6
Antigenic surface determinants of chicken lymphoid cells. II. Selective in vivo and in vitro activity of anti-bursa and anti-thymus sera.鸡淋巴细胞的抗原表面决定簇。II. 抗法氏囊和抗胸腺血清的体内外选择性活性。
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Tolerance induction to cardiac allografts by simultaneous or sequential intrathymic inoculation of disparate alloantigens.通过同时或序贯胸腺内接种不同的同种异体抗原诱导对心脏同种异体移植物的耐受性。
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Characteristics of histocompatibility barriers in congenic strains of mice. III. Passive enhancement of skin allografts in X-irradiated hosts.
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Immune responses of rats deficient in thymus-derived lymphocytes to strong transplantation antigens (Ag-B). Graft-versus-host activity, allograft rejection, and the factor of immunization.胸腺来源淋巴细胞缺陷大鼠对强移植抗原（Ag-B）的免疫反应。移植物抗宿主活性、同种异体移植排斥反应及免疫因子。
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The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers.对于FTY720跨越不同组织相容性主要组织相容性复合体（MHC）屏障延长皮肤同种异体移植存活时间的能力而言，胸腺是必需的。
Transpl Int. 2007 Oct;20(10):895-903. doi: 10.1111/j.1432-2277.2007.00539.x.

引用本文的文献

1
Abnormal response to minor histocompatibility antigens in Obese strain chickens.肥胖品系鸡对次要组织相容性抗原的异常反应。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2877-80. doi: 10.1073/pnas.73.8.2877.
2
Induction of unresponsiveness to major transplantable organs in adult mammals: a recapitulation of ontogeny by irradiation and bone marrow replacement.成年哺乳动物对主要可移植器官无反应性的诱导：通过辐射和骨髓替代对个体发育的重演。
Ann Surg. 1979 Oct;190(4):461-73. doi: 10.1097/00000658-197910000-00006.
3
Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer.

本文引用的文献

1
The use of antigenic tissue extracts to weaken the immunological reaction against skin homografts in mice.使用抗原性组织提取物来减弱小鼠对皮肤同种异体移植的免疫反应。
Transplantation. 1963 Jan;1:21-38. doi: 10.1097/00007890-196301010-00004.
2
Extraction of antigens causing transplantation immunity.引起移植免疫的抗原提取。
Transplant Bull. 1958 Oct;5(4):377-81. doi: 10.1097/00006534-195810000-00034.
3
Tolerance phenomena in birds.鸟类的耐受现象。
胸腺细胞介导的器官同种异体移植特异性无反应性的转移。胸腺细胞转移导致的特异性无反应性。
J Exp Med. 1979 May 1;149(5):1042-55. doi: 10.1084/jem.149.5.1042.
4
Induction of allogeneic unresponsiveness in adult dogs. Role of non-DLA histocompatibility variables in conditioning the outcome of bone marrow, kidney, and skin transplantation in radiation chimeras.成年犬同种异体无反应性的诱导。非DLA组织相容性变量在调节辐射嵌合体中骨髓、肾脏和皮肤移植结果中的作用。
J Clin Invest. 1978 Mar;61(3):790-800. doi: 10.1172/JCI108993.
Proc R Soc Lond B Biol Sci. 1956 Nov 13;146(922):67-77. doi: 10.1098/rspb.1956.0072.
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Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
5
Amplifying and suppressive effect of thymus cells.胸腺细胞的放大和抑制作用。
Nature. 1971 Dec 31;234(5331):549-51. doi: 10.1038/234549a0.
6
Cellular composition of the chicken thymus; effects of neonatal bursectomy and hydrocortisone treatment.鸡胸腺的细胞组成；新生期法氏囊切除和氢化可的松处理的影响
Eur J Immunol. 1973 Dec;3(12):812-8. doi: 10.1002/eji.1830031214.
7
The role of antibody in T-cell responses.抗体在T细胞应答中的作用。
Clin Exp Immunol. 1974 May;17(1):1-18.
8
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
9
Induction fo B cell tolerance by antigen specific T cell factor.抗原特异性T细胞因子诱导B细胞耐受
Nat New Biol. 1973 Mar 21;242(116):82-4.
10
Developmental changes in the cellular composition of the chicken thymus.鸡胸腺细胞组成的发育变化。
Cell Immunol. 1974 May;12(2):186-93. doi: 10.1016/0008-8749(74)90071-9.