Srisankar E V, Patterson L K
Arch Environ Health. 1979 Sep-Oct;34(5):346-9. doi: 10.1080/00039896.1979.10667429.
Ozone concentrations of 0.03 ppm are shown to initiate physical disruption of both oleic and linoleic acid spread monolayers in a few seconds. Approximately equal yields of water soluble products in nitrogen- and oxygen-containing environments as well as in the two acid systems suggest that the dominant reaction pathway involves direct attack on fatty acid double bonds and not oxidative chain reactions. A possible explanation for the observed loss of monolayer material is provided by the Criegee mechanism for ozonide rearrangement following ozone attachment to double bonds. In this scheme polar intermediates are generated which could pass into the aqueous subphase before recombination can occur. alpha-Tocopherol exhibits a protective effect only when present at a high fraction in the fatty acid monolayer (6 mole%). These systems provide an efficient elementary model for studying the physical effects of ozone on lipid membrane structure.
研究表明，浓度为0.03 ppm的臭氧能在几秒钟内引发油酸和亚油酸铺展单分子层的物理破坏。在含氮和含氧环境以及两种酸体系中，水溶性产物的产量大致相等，这表明主要反应途径是直接攻击脂肪酸双键，而非氧化链反应。双键附着臭氧后形成臭氧化物重排的克里奇机制，为观察到的单分子层物质损失提供了一种可能的解释。在该机制中，会生成极性中间体，这些中间体可能在重组发生之前进入水相下层。仅当α-生育酚在脂肪酸单分子层中所占比例较高（6摩尔%）时，才会表现出保护作用。这些体系为研究臭氧对脂质膜结构的物理影响提供了一个有效的基本模型。
