弗氏完全佐剂对输精管结扎大鼠免疫反应的影响。
Effect of Freund's complete adjuvant on the immune response of vasectomized rats.
作者信息
Tonsy M H, Rose N R, Rehewy M E, Hafez E S
出版信息
Arch Androl. 1979 Jun;2(4):323-9. doi: 10.3109/01485017908987333.
PMID:496510
Abstract
Rats were vasectomized, vasectomized and injected in the epididymis with Freund's complete adjuvant (FCA), or only injected with FCA without vasectomy. All were positive for sperm agglutinins, in contrast to sham-operated or untreated controls. Generally, the highest titers were found in vasectomized or unoperated animals given FCA, indicating that local granuloma formation promotes the production of sperm autoantibody, even in nonvasectomized rats.
摘要
将大鼠进行输精管切除术，或进行输精管切除术后在附睾注射弗氏完全佐剂（FCA），或仅注射FCA而不进行输精管切除术。与假手术或未处理的对照组相比，所有组的精子凝集素均呈阳性。一般来说，在接受FCA的输精管切除或未手术的动物中发现了最高滴度，这表明即使在未进行输精管切除术的大鼠中，局部肉芽肿形成也会促进精子自身抗体的产生。
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